Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | USP14 | P54578 | 10/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 2/20 | 0.32 |
| ▸ | USP5 | P45974 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13985417 | 0.88 | HSD11B1 (0.37) | CRHR1HSD11B1AVPR1AUSP14TDP2 | |
| SCHEMBL4755529 | 0.87 | DRD1 (0.39) | CRHR1AVPR1ADRD1DRD5 | |
| SCHEMBL4755531 | 0.87 | DRD1 (0.39) | CRHR1AVPR1ADRD1DRD5 | |
| SCHEMBL13985527 | 0.82 | HSD11B1 (0.36) | CRHR1HSD11B1AVPR1AUSP14RORC | |
| SCHEMBL4756580 | 0.80 | USP14 (0.36) | CRHR1HSD11B1AVPR1AUSP14USP5 | |
| SCHEMBL13985520 | 0.79 | USP14 (0.38) | HSD11B1AVPR1AUSP14TDP2USP5 | |
| SCHEMBL4756663 | 0.79 | RORC (0.35) | CRHR1HSD11B1AVPR1AUSP14RORC | |
| SCHEMBL4755228 | 0.78 | DRD1 (0.40) | CRHR1AVPR1ARORCDRD1DRD5 | |
| SCHEMBL4755225 | 0.78 | DRD1 (0.40) | CRHR1AVPR1ARORCDRD1DRD5 | |
| SCHEMBL4756551 | 0.78 | DRD1 (0.40) | CRHR1AVPR1ARORCDRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |