Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP14 | P54578 | 16/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | USP5 | P45974 | 1/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13985520 | 0.81 | USP14 (0.38) | USP14HSD11B1AVPR1AUSP5USP7 | |
| SCHEMBL13985417 | 0.81 | HSD11B1 (0.37) | USP14HSD11B1AVPR1AUSP5USP7 | |
| SCHEMBL13985228 | 0.80 | CRHR1 (0.35) | USP14HSD11B1AVPR1AUSP5USP7 | |
| SCHEMBL4756663 | 0.79 | RORC (0.35) | USP14HSD11B1AVPR1ACRHR1 | |
| SCHEMBL13985527 | 0.77 | HSD11B1 (0.36) | USP14HSD11B1AVPR1AUSP5USP7 | |
| SCHEMBL13985227 | 0.75 | NOTUM (0.39) | USP14HSD11B1USP5USP7 | |
| SCHEMBL3177168 | 0.75 | PDE4B (0.42) | USP14HSD11B1AVPR1A | |
| SCHEMBL3177174 | 0.75 | PDE4B (0.42) | USP14HSD11B1AVPR1A | |
| SCHEMBL3169024 | 0.74 | CTSS (0.36) | USP14HSD11B1AVPR1A | |
| SCHEMBL3169031 | 0.74 | CTSS (0.36) | USP14HSD11B1AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | claimed |