Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.51 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13990444 | 0.91 | GPR35 (0.41) | GPR35DCLRE1BNR4A1NR4A2NR4A3 | |
| SCHEMBL13990442 | 0.86 | DHODH (0.48) | GPR35NR4A1NR4A2NR4A3TYMS | |
| SCHEMBL13990449 | 0.86 | FOLH1 (0.47) | TYMSDHODHCYSLTR1KDM4EALDH1A1 | |
| SCHEMBL13990447 | 0.85 | DCLRE1B (0.44) | DCLRE1BTYMSDHODHGABRPGABRD | |
| SCHEMBL13990441 | 0.84 | MCL1 (0.45) | KDM4EALDH1A1TRPM2KMO | |
| SCHEMBL13990443 | 0.81 | TYMS (0.40) | GPR35DCLRE1BTYMSDHODHCYSLTR1 | |
| SCHEMBL13990445 | 0.80 | RXRA (0.44) | TYMSDHODHCYSLTR1KDM4EALDH1A1 | |
| SCHEMBL13990448 | 0.79 | GPR35 (0.46) | GPR35NR4A1NR4A2NR4A3TYMS | |
| SCHEMBL13990451 | 0.74 | TYMS (0.44) | NR4A1NR4A2NR4A3TYMSDHODH | |
| SCHEMBL17797037 | 0.73 | DCLRE1B (0.56) | GPR35DCLRE1BNR4A1NR4A2NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080319175-A1 | Transthyretin Stabilization | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-25 | — | — | US | disclosed |
| US-20080319175-A1 | Transthyretin Stabilization | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319175-A1 | Transthyretin Stabilization | TTR, TTPA, ALB | GPR35 4535/4885DCLRE1B 1609/4885NR4A1 2206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.