Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | BAD | Q92934 | 3/20 | 0.45 |
| ▸ | RORC | P51449 | 3/20 | 0.44 |
| ▸ | RORB | Q92753 | 3/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.41 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | MPL | P40238 | 1/20 | 0.40 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13990445 | 0.92 | RXRA (0.44) | MCL1BADRORCRORBAKR1C3 | |
| SCHEMBL13990446 | 0.84 | GPR35 (0.51) | KDM4EALDH1A1KMOTRPM2 | |
| SCHEMBL13990442 | 0.83 | DHODH (0.48) | ALOX15KDM4EALDH1A1PTPN2PTPN1 | |
| SCHEMBL13990449 | 0.83 | FOLH1 (0.47) | AKR1C3AKR1C2KDM4EALDH1A1KMO | |
| SCHEMBL13990447 | 0.81 | DCLRE1B (0.44) | MCL1BADRORBBCL2L1ALOX15 | |
| SCHEMBL13990444 | 0.80 | GPR35 (0.41) | PTPN2PTPN1 | |
| SCHEMBL13990416 | 0.78 | MPO (0.58) | AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL13990437 | 0.78 | CYSLTR1 (0.44) | AKR1C3AKR1C2KDM4EALDH1A1 | |
| SCHEMBL13990443 | 0.78 | TYMS (0.40) | PTPN2PTPN1PTPN22 | |
| SCHEMBL2149269 | 0.77 | CYP1A1 (0.65) | ALOX15KDM4EALDH1A1SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080319175-A1 | Transthyretin Stabilization | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-25 | — | — | US | disclosed |
| US-20080319175-A1 | Transthyretin Stabilization | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319175-A1 | Transthyretin Stabilization | TTR, TTPA, ALB | MCL1 2542/4885BAD 3383/4885RORC 3279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.