Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | BAD | Q92934 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | EIF4E | P06730 | 1/20 | 0.36 |
| ▸ | RORB | Q92753 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13990441 | 0.92 | MCL1 (0.45) | XDHSLC22A12MCL1BADAKR1C3 | |
| SCHEMBL13990444 | 0.84 | GPR35 (0.41) | TYMSCYSLTR1DHODH | |
| SCHEMBL13990442 | 0.82 | DHODH (0.48) | TYMSCYSLTR1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL13990443 | 0.81 | TYMS (0.40) | RXRARXRBTYMSCYSLTR1DHODH | |
| SCHEMBL13990421 | 0.80 | TAS2R14 (0.50) | AKR1C3AKR1C2 | |
| SCHEMBL13990446 | 0.80 | GPR35 (0.51) | TYMSCYSLTR1KDM4EALDH1A1HPGD | |
| SCHEMBL13990449 | 0.79 | FOLH1 (0.47) | RXRARXRBTYMSCYSLTR1AKR1C3 | |
| SCHEMBL13990447 | 0.78 | DCLRE1B (0.44) | TYMSCYSLTR1MCL1BADRORB | |
| SCHEMBL13990416 | 0.74 | MPO (0.58) | AKR1C3AKR1C2ALDH1A1DHODH | |
| SCHEMBL13990437 | 0.74 | CYSLTR1 (0.44) | CYSLTR1AKR1C3AKR1C2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080319175-A1 | Transthyretin Stabilization | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-25 | — | — | US | disclosed |
| US-20080319175-A1 | Transthyretin Stabilization | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319175-A1 | Transthyretin Stabilization | TTR, TTPA, ALB | RXRA 2592/4885RXRB 2825/4885XDH 2793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.