Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | DDT | P30046 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | PTPRF | P10586 | 2/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13990442 | 0.88 | DHODH (0.48) | FOLH1PTPN1PTPRFPTPN2TYMS | |
| SCHEMBL13990447 | 0.86 | DCLRE1B (0.44) | TYMSL3MBTL1DHODHCYSLTR1 | |
| SCHEMBL13990446 | 0.86 | GPR35 (0.51) | KMOTYMSKDM4EALDH1A1DHODH | |
| SCHEMBL13990441 | 0.83 | MCL1 (0.45) | PTPN1PTPN2KMOPTPN11KDM4E | |
| SCHEMBL13990443 | 0.82 | TYMS (0.40) | PTPN1PTPRFPTPN2TYMSDHODH | |
| SCHEMBL13990444 | 0.82 | GPR35 (0.41) | PTPN1PTPRFPTPN2TYMSDHODH | |
| SCHEMBL13990445 | 0.79 | RXRA (0.44) | TYMSKDM4EALDH1A1DHODHAKR1C3 | |
| SCHEMBL13990450 | 0.77 | MCL1 (0.45) | PTPN1PTPRFPTPN2TYMSMYC | |
| SCHEMBL13990425 | 0.76 | AKR1C3 (0.56) | MYCL3MBTL1AKR1C3AKR1C2 | |
| SCHEMBL13990448 | 0.75 | GPR35 (0.46) | TYMSKDM4EALDH1A1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080319175-A1 | Transthyretin Stabilization | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-25 | — | — | US | disclosed |
| US-20080319175-A1 | Transthyretin Stabilization | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319175-A1 | Transthyretin Stabilization | TTR, TTPA, ALB | FOLH1 2132/4885DDT 87/4885PTPN1 3112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.