Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14005177 | 0.91 | KDM4E (0.48) | TSHRKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL14005192 | 0.81 | MAPT (0.54) | TSHRKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4889055 | 0.73 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL14025800 | 0.73 | MAPT (0.66) | TSHRKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4898157 | 0.72 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL14005199 | 0.72 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDPOLBMAPK1 | |
| SCHEMBL7080320 | 0.71 | MAPT (0.73) | TSHRKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL18782204 | 0.71 | SLC40A1 (0.59) | TSHRMAPTPOLBMAPK10KMT2A | |
| SCHEMBL14025441 | 0.70 | SMN1; SMN2 (0.64) | TSHRKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL14025799 | 0.70 | ITGB3 (0.53) | KDM4EALDH1A1SMN1; SMN2KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293711-A1 | Chemokine receptor modulators | METASTATIX, INC. | 2008-11-27 | — | — | US | disclosed |
| US-20080293711-A1 | Chemokine receptor modulators | METASTATIX, INC. | 2008-11-27 | — | — | US | disclosed |
| WO-2008112156-A1 | CHEMOKINE RECEPTOR MODULATORS | ALTIRIS THERAPEUTICS (US) | 2008-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293711-A1 | Chemokine receptor modulators | CCR5, CCL2, CXCR4 | TSHR 2114/4885KDM4E 4332/4885ALDH1A1 1359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.