Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 11/20 | 0.83 |
| ▸ | TUBB | P07437 | 11/20 | 0.83 |
| ▸ | TUBA3C | P0DPH7 | 11/20 | 0.83 |
| ▸ | TUBA1B | P68363 | 11/20 | 0.83 |
| ▸ | TUBA4A | P68366 | 11/20 | 0.83 |
| ▸ | TUBB4B | P68371 | 11/20 | 0.83 |
| ▸ | TUBB3 | Q13509 | 11/20 | 0.83 |
| ▸ | TUBB2A | Q13885 | 11/20 | 0.83 |
| ▸ | TUBB8 | Q3ZCM7 | 11/20 | 0.83 |
| ▸ | TUBA3E | Q6PEY2 | 11/20 | 0.83 |
| ▸ | TUBA1A | Q71U36 | 11/20 | 0.83 |
| ▸ | TUBA1C | Q9BQE3 | 11/20 | 0.83 |
| ▸ | TUBB6 | Q9BUF5 | 11/20 | 0.83 |
| ▸ | TUBB2B | Q9BVA1 | 11/20 | 0.83 |
| ▸ | TUBB1 | Q9H4B7 | 11/20 | 0.83 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.83 |
| ▸ | GNG2 | P59768 | 1/20 | 0.65 |
| ▸ | GNB1 | P62873 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12091269 | 1.00 | TUBB4A (0.83) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL30418517 | 0.91 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5434553 | 0.91 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1401455 | 0.91 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL12091262 | 0.89 | TUBB4A (0.78) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL18866851 | 0.87 | GNG2 (0.69) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL12094188 | 0.87 | TUBB4A (0.63) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1401409 | 0.86 | TUBB4A (0.83) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2619296 | 0.86 | GNG2 (0.67) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL21104787 | 0.86 | GNG2 (0.84) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283092-A1 | METHODS AND USES OF COLCHICINE DERIVATIVES | ALBERTA HEALTH SERVICES (CA) | 2021-09-16 | — | — | US | disclosed |
| US-20210283092-A1 | METHODS AND USES OF COLCHICINE DERIVATIVES | ALBERTA HEALTH SERVICES (CA) | 2021-09-16 | — | — | US | disclosed |
| EP-3813821-A1 | METHODS AND USES OF COLCHICINE DERIVATIVES | Alberta Health Services (CA) | 2021-05-05 | — | — | EP | disclosed |
| EP-2470499-B1 | NOVEL COLCHICINE DERIVATIVES, METHODS AND USES THEREOF | ALBERTA HEALTH SERVICES (CA) | 2019-06-12 | — | — | EP | disclosed |
| EP-2452931-B1 | METHOD FOR PREPARING TRICYCLIC DERIVATIVES | JE IL PHARMACEUTICAL CO LTD (KR) | 2017-05-17 | — | — | EP | disclosed |
| EP-2452931-B1 | METHOD FOR PREPARING TRICYCLIC DERIVATIVES | JE IL PHARMACEUTICAL CO LTD (KR) | 2017-05-17 | — | — | EP | disclosed |
| US-8742160-B2 | Method for preparing tricyclic derivatives | JE IL PHARMACEUTICAL CO., LTD. (KR) | 2014-06-03 | — | — | US | disclosed |
| US-8742160-B2 | Method for preparing tricyclic derivatives | JE IL PHARMACEUTICAL CO., LTD. (KR) | 2014-06-03 | — | — | US | disclosed |
| EP-2452931-A2 | METHOD FOR PREPARING TRICYCLIC DERIVATIVES | Jeil Pharmaceutical Co., Ltd. (KR) | 2012-05-16 | — | — | EP | disclosed |
| US-20120101296-A1 | METHOD FOR PREPARING TRICYCLIC DERIVATIVES | JE IL PHARMACEUTICAL CO., LTD. (KR) | 2012-04-26 | — | — | US | disclosed |
| US-20120101296-A1 | METHOD FOR PREPARING TRICYCLIC DERIVATIVES | JE IL PHARMACEUTICAL CO., LTD. (KR) | 2012-04-26 | — | — | US | disclosed |
| EP-1646608-B1 | TRICYCLIC DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JE IL PHARMACEUTICAL CO LTD (KR) | 2011-03-02 | — | — | EP | disclosed |
| US-20070179143-A1 | Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them | JE IL PHARMACEUTICAL CO., LTD. (KR) | 2007-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179143-A1 | Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them | VEGFA, TUBB3, TUBA3C | TUBB4A 10/4885TUBB 7/4885TUBA3C 3/4885 |
| US-20120101296-A1 | METHOD FOR PREPARING TRICYCLIC DERIVATIVES | NISCH, CA3, CYP51A1 | TUBB4A 2554/4885TUBB 3311/4885TUBA3C 2667/4885 |
| US-20210283092-A1 | METHODS AND USES OF COLCHICINE DERIVATIVES | IL1B, IL6, TUBB | TUBB4A 18/4885TUBB 3/4885TUBA3C 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.