Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.36 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | SELE | P16581 | 1/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14030952 | 0.81 | DGAT2 (0.39) | MAPTBACE1CHRNB2CHRNA4DGAT2 | |
| SCHEMBL14005605 | 0.78 | RAB9A (0.39) | NPC1RAB9ALTA4HMAPK14MAPT | |
| SCHEMBL14030057 | 0.77 | GCK (0.36) | GCKCHRNB2CHRNA4NOS3NOS1 | |
| SCHEMBL14030954 | 0.77 | ICAM1 (0.38) | GCKCHRNB2CHRNA4NOS3NOS1 | |
| SCHEMBL4741489 | 0.76 | ALDH1A1 (0.48) | HTTDGAT2 | |
| SCHEMBL14030070 | 0.74 | LOXL2 (0.40) | NPC1RAB9AHTTSMN1; SMN2GCK | |
| SCHEMBL14031023 | 0.72 | MPO (0.44) | LTA4HCHRNB2CHRNA4NOS3NOS1 | |
| SCHEMBL14030985 | 0.72 | CHRNB2 (0.40) | NPC1RAB9ASMN1; SMN2GCKCHRNB2 | |
| SCHEMBL3209263 | 0.72 | NPC1 (0.45) | NPC1RAB9ALTA4HMAPK14MAPT | |
| SCHEMBL3200250 | 0.72 | NPC1 (0.51) | NPC1RAB9ALTA4HMAPK14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | PDPK1, PDK2, PDK3 | NPC1 2507/4885RAB9A 1685/4885LTA4H 3917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.