Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 5/20 | 0.55 |
| ▸ | PLAU | P00749 | 17/20 | 0.51 |
| ▸ | PLG | P00747 | 14/20 | 0.51 |
| ▸ | ST14 | Q9Y5Y6 | 4/20 | 0.51 |
| ▸ | F2 | P00734 | 3/20 | 0.51 |
| ▸ | PLAT | P00750 | 3/20 | 0.50 |
| ▸ | HPN | P05981 | 2/20 | 0.49 |
| ▸ | HGFAC | Q04756 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18049253 | 0.83 | ST14 (0.74) | F10PLAUPLGST14F2 | |
| SCHEMBL18049399 | 0.83 | ST14 (0.74) | F10PLAUPLGST14F2 | |
| SCHEMBL13866917 | 0.82 | PLAU (0.78) | F10PLAUPLGST14F2 | |
| SCHEMBL12618903 | 0.82 | PLAU (0.78) | F10PLAUPLGST14F2 | |
| SCHEMBL6266784 | 0.81 | F10 (0.82) | F10PLAUPLGST14F2 | |
| SCHEMBL13866546 | 0.81 | F10 (0.55) | F10PLAUPLGST14F2 | |
| SCHEMBL485675 | 0.80 | MMP2 (0.66) | — | |
| SCHEMBL485678 | 0.80 | MMP2 (0.66) | — | |
| SCHEMBL4588880 | 0.80 | F10 (0.66) | F10PLAUPLGST14F2 | |
| SCHEMBL19923004 | 0.79 | MMP2 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169676-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | WASHINGTON UNIVERSITY (US) | 2022-06-02 | — | — | US | disclosed |
| US-11130780-B2 | Inhibitors of growth factor activation enzymes | WASHINGTON UNIVERSITY (US) | 2021-09-28 | — | — | US | disclosed |
| US-20180066015-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | WASHINGTON UNIVERSITY (US) | 2018-03-08 | — | — | US | disclosed |
| WO-2016144654-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | WASHINGTON UNIVERSITY (US) | 2016-09-15 | — | — | WO | disclosed |
| US-20080261998-A1 | Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors | WILEX AG (DE) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11130780-B2 | Inhibitors of growth factor activation enzymes | HDGF, MMP7, HGF | F10 95/4885PLAU 46/4885PLG 91/4885 |
| US-20220169676-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | HDGF, MMP7, HGF | F10 95/4885PLAU 46/4885PLG 91/4885 |
| US-20080261998-A1 | Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors | PLAU, PLAUR, HPN | F10 1217/4885PLAU 1/4885PLG 6/4885 |
| US-20180066015-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | HDGF, MMP7, HGF | F10 95/4885PLAU 46/4885PLG 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.