Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16316790 | 0.83 | SMN1; SMN2 (0.65) | MAOBSMN1; SMN2WDR5PKMBACE1 | |
| SCHEMBL28868246 | 0.81 | LMNA (0.47) | MAOBSMN1; SMN2WDR5PKMBACE1 | |
| SCHEMBL11140481 | 0.80 | MAOB (0.46) | MAOBSMN1; SMN2PKMAPPBACE1 | |
| SCHEMBL407215 | 0.79 | L3MBTL1 (0.64) | TRPV4SMN1; SMN2L3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL38243330 | 0.79 | TRPV4 (0.73) | TRPV4SMN1; SMN2WDR5L3MBTL1ALDH1A1 | |
| SCHEMBL29482636 | 0.79 | L3MBTL1 (0.64) | TRPV4SMN1; SMN2L3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL5012595 | 0.79 | SMN1; SMN2 (0.59) | TRPV4SMN1; SMN2PKML3MBTL1ALDH1A1 | |
| SCHEMBL750886 | 0.79 | TRPV4 (0.73) | TRPV4SMN1; SMN2WDR5L3MBTL1ALDH1A1 | |
| SCHEMBL739940 | 0.79 | KMT2A (0.60) | TRPV4SMN1; SMN2L3MBTL1ALDH1A1POLB | |
| SCHEMBL14520042 | 0.79 | MAOB (0.44) | MAOBSMN1; SMN2WDR5PKMBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299055-B2 | 8-substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2012-10-30 | — | — | US | disclosed |
| US-20100261701-A1 | 8-Substituted isoquinoline derivative and the use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261701-A1 | 8-Substituted isoquinoline derivative and the use thereof | RELA, NFKBIA, NFKB2 | TRPV4 3854/4885MAOB 4096/4885SMN1; SMN2 3014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.