Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1407026 | 0.98 | CNR2 (0.39) | CNR2HSD11B1NR3C1HCAR3GRM1 | |
| SCHEMBL1407004 | 0.95 | HCAR3 (0.38) | CNR2HSD11B1NR3C1HCAR3KEAP1 | |
| SCHEMBL1406946 | 0.92 | KEAP1 (0.40) | HSD11B1NR3C1HCAR3KEAP1NFE2L2 | |
| SCHEMBL1406924 | 0.86 | LRRK2 (0.37) | HSD11B1NR3C1HCAR3KEAP1NFE2L2 | |
| SCHEMBL1406919 | 0.86 | LRRK2 (0.37) | HSD11B1NR3C1HCAR3KEAP1NFE2L2 | |
| SCHEMBL1406557 | 0.84 | NR3C1 (0.43) | HSD11B1NR3C1KDM4CS1PR1 | |
| SCHEMBL17110193 | 0.82 | HSD11B1 (0.40) | HSD11B1NR3C1KEAP1NFE2L2KDM4E | |
| SCHEMBL6052465 | 0.81 | TRPV4 (0.45) | CNR2HSD11B1NR3C1HCAR3KDM4E | |
| SCHEMBL27737776 | 0.81 | HSD11B1 (0.40) | CNR2HSD11B1HCAR3KEAP1NFE2L2 | |
| SCHEMBL27758267 | 0.79 | ALOX15 (0.41) | HSD11B1HCAR3KEAP1NFE2L2KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101405270-B | Pyrazoles as 11-beta-HSD-1 | HOFFMANN LA ROCHE | 2013-01-16 | — | — | CN | claimed |
| EP-2295411-A1 | Pyrazoles as 11-beta-hsd-1 | F. Hoffmann-La Roche AG (CH) | 2011-03-16 | — | — | EP | claimed |
| CN-101405270-A | Pyrazoles as 11-beta-HSD-1 | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | CN | claimed |
| EP-1999114-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. Hoffmann-la Roche AG (CH) | 2008-12-10 | — | — | EP | claimed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | claimed |
| EP-1999114-B1 | PYRAZOLES AS 11-BETA-HSD-1 | HOFFMANN LA ROCHE (CH) | 2015-07-22 | — | — | EP | disclosed |
| CN-101405270-B | Pyrazoles as 11-beta-HSD-1 | HOFFMANN LA ROCHE | 2013-01-16 | — | — | CN | disclosed |
| EP-2295411-A1 | Pyrazoles as 11-beta-hsd-1 | F. Hoffmann-La Roche AG (CH) | 2011-03-16 | — | — | EP | disclosed |
| US-7728029-B2 | Adamantyl-pyrazole carboxamides as inhibitors of 11β-hdroxysteroid dehydrogenase | HOFFMANN-LA ROCHE INC. (US) | 2010-06-01 | — | — | US | disclosed |
| CN-101405270-A | Pyrazoles as 11-beta-HSD-1 | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | CN | disclosed |
| EP-1999114-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. Hoffmann-la Roche AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |
| US-20070225280-A1 | Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase | ANDERSON KEVIN WILLIAM | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225280-A1 | Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase | HSD3B2, HSD3B1, HSD17B2 | CNR2 2639/4885HSD11B1 6/4885NR3C1 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.