Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14073608 | 0.92 | MAPT (0.57) | CYP3A4CYP19A1CYP1A2HSF1PABPC1 | |
| SCHEMBL22284873 | 0.88 | CYP3A4 (0.58) | CYP3A4CYP19A1CYP1A2HSF1CYP2C9 | |
| SCHEMBL14073935 | 0.88 | MAPT (0.64) | CYP3A4CYP19A1CYP1A2CYP2C9NPC1 | |
| SCHEMBL14073802 | 0.87 | CYP3A4 (0.56) | CYP3A4CYP19A1CYP1A2CYP2C9NPC1 | |
| SCHEMBL14073885 | 0.82 | KMT2A (0.55) | CYP3A4CYP19A1CYP1A2CYP2C9NPC1 | |
| SCHEMBL14073931 | 0.81 | CYP3A4 (0.56) | CYP3A4CYP19A1CYP1A2CYP2C9NPC1 | |
| SCHEMBL14073692 | 0.81 | ALDH1A1 (0.72) | CYP3A4CYP19A1CYP1A2CYP2C9NPC1 | |
| SCHEMBL14073783 | 0.80 | CYP3A4 (0.70) | CYP3A4CYP19A1CYP1A2CYP2C9NPC1 | |
| SCHEMBL14073902 | 0.80 | RAB9A (0.60) | CYP3A4CYP19A1CYP1A2CYP2C9NPC1 | |
| SCHEMBL14073772 | 0.80 | NPC1 (0.61) | CYP3A4CYP19A1CYP1A2CYP2C9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221093-A1 | Metalloprotease inhibitors containing a heterocyclic moiety | ALANTOS PHARMACEUTICALS HOLDING, INC. | 2008-09-11 | — | — | US | disclosed |
| US-20080221093-A1 | Metalloprotease inhibitors containing a heterocyclic moiety | ALANTOS PHARMACEUTICALS HOLDING, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221093-A1 | Metalloprotease inhibitors containing a heterocyclic moiety | MMP12, MMP13, MMP25 | CYP3A4 376/4885CYP19A1 651/4885CYP1A2 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.