SCHEMBL14080306

SCHEMBL14080306

O=C1/C(=C/c2ccc(/C=C3/C(=O)C4CCC3C4)cc2)C2CCC1C2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.38
LMNA P02545 4/20 0.38
SMN1; SMN2 Q16637 4/20 0.38
HTT P42858 1/20 0.38
NPC1 O15118 5/20 0.37
RAB9A P51151 4/20 0.37
ALDH1A1 P00352 6/20 0.36
KDM4E B2RXH2 2/20 0.36
CYP1A2 P05177 2/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
NR1I2 O75469 1/20 0.35
KMT2A Q03164 3/20 0.34
MAPK1 P28482 3/20 0.34
GAA P10253 1/20 0.34
MEN1 O00255 1/20 0.33
HPGD P15428 2/20 0.32
CHRNA7 P36544 1/20 0.31
NFKB1 P19838 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4665877 0.90 CYP1A2 (0.47) MAPTLMNASMN1; SMN2HTTALDH1A1
SCHEMBL94584 0.90 CYP1A2 (0.47) MAPTLMNASMN1; SMN2HTTALDH1A1
SCHEMBL7839741 0.87 MEN1 (0.38) MAPTLMNASMN1; SMN2HTTNPC1
SCHEMBL13299668 0.84 NPC1 (0.50) MAPTSMN1; SMN2HTTNPC1RAB9A
SCHEMBL22667801 0.82
SCHEMBL9335352 0.71
SCHEMBL16582576 0.71
SCHEMBL19060090 0.71
SCHEMBL7839790 0.70 ALDH1A1 (0.45) MAPTLMNASMN1; SMN2NPC1RAB9A
SCHEMBL15822005 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'OREAL (FR) 2021-11-11 US disclosed
EP-3185843-B1 GEL COMPOSITION AND GEL COMPRISING A UV FILTER OREAL (FR) 2021-08-11 EP disclosed
EP-2872107-B1 COSMETIC COMPOSITION CONTAINING SCREENING COMPOSITE PARTICLES OREAL (FR) 2021-07-21 EP disclosed
US-20200360264-A1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT L'OREAL (FR) 2020-11-19 US disclosed
US-20200030200-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'OREAL (FR) 2020-01-30 US disclosed
US-20170326045-A1 COSMETIC COMPOSITION COMPRISING A SYNTHETIC PHYLLOSILICATE AND A POLYOL AND/OR A UV FILTER L'OREAL (FR) 2017-11-16 US disclosed
US-20170326045-A1 COSMETIC COMPOSITION COMPRISING A SYNTHETIC PHYLLOSILICATE AND A POLYOL AND/OR A UV FILTER L'OREAL (FR) 2017-11-16 US disclosed
US-20170304658-A1 GEL/GEL COMPOSITION COMPRISING A UV-SCREENING AGENT L'OREAL (FR) 2017-10-26 US disclosed
US-20170304658-A1 GEL/GEL COMPOSITION COMPRISING A UV-SCREENING AGENT L'OREAL (FR) 2017-10-26 US disclosed
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2015-07-09 US disclosed
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2015-07-09 US disclosed
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES L'OREAL (FR) 2015-06-11 US disclosed
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES L'OREAL (FR) 2015-06-11 US disclosed
WO-2014010098-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES L'OREAL (FR) 2014-01-16 WO disclosed
WO-2014010099-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARING THE SAME L'OREAL (FR) 2014-01-16 WO disclosed
WO-2014009097-A1 COSMETIC COMPOSITION CONTAINING SCREENING COMPOSITE PARTICLES L'OREAL (FR) 2014-01-16 WO disclosed
WO-2014010100-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2014-01-16 WO disclosed
US-7416721-B2 Sunscreen compositions comprising insoluble organic UV-screening agents and hydroxyalkylurea compounds L'OREAL (FR) 2008-08-26 US disclosed
US-7166274-B2 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds L'OREAL (FR) 2007-01-23 US disclosed
US-7166274-B2 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds L'OREAL (FR) 2007-01-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200360264-A1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT PCNA, ERCC1, XRCC6 MAPT 483/4885LMNA 924/4885SMN1; SMN2 1920/4885
US-20170326045-A1 COSMETIC COMPOSITION COMPRISING A SYNTHETIC PHYLLOSILICATE AND A POLYOL AND/OR A UV FILTER PUF60, POLR1C, DPM1 MAPT 938/4885LMNA 2324/4885SMN1; SMN2 3638/4885
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES MITF, RAB5IF, TYR MAPT 922/4885LMNA 683/4885SMN1; SMN2 2367/4885
US-20200030200-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER ERCC5, CUTA, PLIN5 MAPT 2849/4885LMNA 77/4885SMN1; SMN2 4095/4885
US-20170304658-A1 GEL/GEL COMPOSITION COMPRISING A UV-SCREENING AGENT CUTA, KRT18, APOL1 MAPT 369/4885LMNA 31/4885SMN1; SMN2 3992/4885
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER ERCC5, CUTA, PLIN5 MAPT 2849/4885LMNA 77/4885SMN1; SMN2 4095/4885
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES XPA, ERCC1, ERCC4 MAPT 2352/4885LMNA 942/4885SMN1; SMN2 763/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.