Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21212677 | 0.79 | GRM4 (0.36) | GRM4HTR2AHTR2CHTR2B | |
| SCHEMBL1878783 | 0.77 | CYP2A6 (0.76) | CYP1A2CYP2A6AKR1C3AKR1C2RIOK2 | |
| SCHEMBL29475635 | 0.77 | CYP2A6 (0.76) | CYP1A2CYP2A6AKR1C3AKR1C2RIOK2 | |
| SCHEMBL805508 | 0.77 | CYP1A2 (0.53) | CYP1A2CYP2A6AKR1C3AKR1C2RIOK2 | |
| SCHEMBL10199297 | 0.77 | GRM4 (0.42) | CYP1A2CYP2A6GRM4TRPA1NPC1 | |
| SCHEMBL10262506 | 0.77 | CYP1A2 (0.54) | CYP1A2CYP2A6GRM4HTR2AHTR2C | |
| SCHEMBL20285552 | 0.75 | ESR1 (0.38) | GRM4HTR2AHTR2CHTR2BESR1 | |
| SCHEMBL12064450 | 0.75 | NOS3 (0.53) | CYP1A2CYP2A6AKR1C3AKR1C2NOS3 | |
| SCHEMBL18563394 | 0.75 | GRM4 (0.44) | GRM4NOS3NOS1NOS2RAB9A | |
| SCHEMBL19843833 | 0.75 | CYP1A2 (0.47) | CYP1A2CYP2A6AKR1C3AKR1C2RIOK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230145003-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-05-11 | — | — | US | disclosed |
| US-20080221093-A1 | Metalloprotease inhibitors containing a heterocyclic moiety | ALANTOS PHARMACEUTICALS HOLDING, INC. | 2008-09-11 | — | — | US | disclosed |
| US-20080221094-A1 | Metalloprotease inhibitors containing a squaramide moiety | ALANTOS PHARMACEUTICALS HOLDING, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221093-A1 | Metalloprotease inhibitors containing a heterocyclic moiety | MMP12, MMP13, MMP25 | CYP1A2 415/4885CYP2A6 569/4885AKR1C3 1944/4885 |
| US-20080221094-A1 | Metalloprotease inhibitors containing a squaramide moiety | MMP13, MMP14, MMP11 | CYP1A2 3061/4885CYP2A6 2323/4885AKR1C3 3372/4885 |
| US-20230145003-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | CYP1A2 3256/4885CYP2A6 2405/4885AKR1C3 3263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.