Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.44 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200735 | 0.93 | APP (0.47) | ALDH1A1HTTMEN1MAPTKMT2A | |
| SCHEMBL14543451 | 0.92 | ALDH1A1 (0.44) | ALDH1A1HTTMEN1MAPTKMT2A | |
| SCHEMBL14229225 | 0.86 | HDAC3 (0.51) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL14200796 | 0.82 | TSPO (0.48) | HDAC1HDAC6EPHX2 | |
| SCHEMBL14200780 | 0.81 | HDAC6 (0.48) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL14200763 | 0.80 | SIGMAR1 (0.42) | ALDH1A1EPHX2 | |
| SCHEMBL14200848 | 0.80 | TSHR (0.50) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL14200903 | 0.80 | RIPK1 (0.49) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL14200770 | 0.79 | EPHX2 (0.44) | EPHX2 | |
| SCHEMBL14200923 | 0.79 | USP2 (0.45) | HDAC3HDAC1HDAC2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |