SCHEMBL1425504

SCHEMBL1425504

Nc1c(Cl)c(Br)nc(C(=O)O)c1Cl

nearest known ligand 0.66

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.66
MAPT P10636 2/20 0.33
ATM Q13315 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
PLAU P00749 2/20 0.33
LMNA P02545 1/20 0.33
GAA P10253 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33
KMO O15229 1/20 0.31
COPS5 Q92905 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21806451 0.83 TDP1 (0.55) TDP1PLAUHCAR2
SCHEMBL30151452 0.83 TDP1 (0.55) TDP1PLAUHCAR2
Picloram SCHEMBL8467014 0.79 TDP1 (1.00) TDP1MAPTATML3MBTL1PLAU
Picloram SCHEMBL13299 0.79 TDP1 (1.00) TDP1MAPTATML3MBTL1PLAU
Picloram SCHEMBL29388079 0.79 TDP1 (1.00) TDP1MAPTATML3MBTL1PLAU
SCHEMBL2346962 0.79 TDP1 (0.42) TDP1HCAR2KMO
SCHEMBL2344376 0.78 TDP1 (0.69) TDP1MAPTATML3MBTL1PLAU
Picloram SCHEMBL5086801 0.78 TDP1 (0.96) TDP1MAPTATML3MBTL1PLAU
Picloram SCHEMBL15437675 0.78 TDP1 (0.96) TDP1MAPTATML3MBTL1PLAU
Picloram SCHEMBL7112378 0.78 TDP1 (0.96) TDP1MAPTATML3MBTL1PLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1608624-B1 6-ALKYL OR ALKENYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2011-03-23 EP disclosed
EP-1651607-B1 6-(1,1-DIFLUOROALKYL)-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2009-05-06 EP disclosed
US-7432227-B2 6-alkyl or alkenyl-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2008-10-07 US disclosed
US-7291580-B2 6-(1,1-difluoroalkyl)-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2007-11-06 US disclosed
EP-1246802-B1 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2007-03-14 EP disclosed
US-20050032651-A1 6-(1,1-Difluoroalkyl)-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC 2005-02-10 US disclosed
EP-1414814-B1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2005-02-02 EP disclosed
US-20040198608-A1 6-Alkyl or alkenyl-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2004-10-07 US disclosed
US-6784137-B2 SUCH AS 5,6-DICHLOROPYRIDINE-2-CARBOXYLIC ACID-N-OXIDE FOR PREEMERGENCE APPLICATION DOW AGROSCIENCES LLC 2004-08-31 US disclosed
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2003-06-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050032651-A1 6-(1,1-Difluoroalkyl)-4-aminopicolinates and their use as herbicides DDT, ALDH7A1, DDC TDP1 2566/4885MAPT 887/4885ATM 3691/4885
US-20040198608-A1 6-Alkyl or alkenyl-4-aminopicolinates and their use as herbicides AADAC, AASDHPPT, AADAT TDP1 3420/4885MAPT 614/4885ATM 3169/4885
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides AADAC, DDT, AADAT TDP1 3914/4885MAPT 526/4885ATM 3561/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.