Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 2/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313192 | 0.92 | SLC22A12 (0.34) | SLC22A12ENPP3MTNR1APARP1HPGDS | |
| SCHEMBL14312879 | 0.88 | ENPP3 (0.36) | SLC22A12ENPP3MTNR1APARP1ALDH1A1 | |
| SCHEMBL14312982 | 0.85 | TGFBR1 (0.37) | TGFBR1TSHRPDE10ACYP2E1CYP3A4 | |
| SCHEMBL3220570 | 0.84 | HPGDS (0.46) | TGFBR1SLC22A12ENPP3TSHRPDE10A | |
| SCHEMBL14313094 | 0.83 | TGFBR1 (0.35) | TGFBR1SLC22A12TSHRCYP2E1CYP3A4 | |
| SCHEMBL14313355 | 0.83 | TGFBR1 (0.35) | TGFBR1SLC22A12TSHRCYP2E1CYP3A4 | |
| SCHEMBL14312671 | 0.83 | HPGDS (0.46) | SLC22A12ALDH1A1HPGDSL3MBTL1 | |
| SCHEMBL14312986 | 0.83 | TGFBR1 (0.35) | TGFBR1TSHRALDH1A1HPGD | |
| SCHEMBL14312830 | 0.82 | HPGDS (0.37) | TGFBR1TSHRALDH1A1HPGDHPGDS | |
| SCHEMBL14312735 | 0.82 | TGFBR1 (0.35) | TGFBR1TSHRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |