Water

Water

SCHEMBL1436264

O.O=S(O)c1ccccc1

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 known ✓ O15379 1/20 0.33
HDAC4 known ✓ P56524 1/20 0.33
HDAC1 known ✓ Q13547 1/20 0.33
HDAC7 known ✓ Q8WUI4 1/20 0.33
HDAC2 known ✓ Q92769 1/20 0.33
HDAC10 known ✓ Q969S8 1/20 0.33
HDAC11 known ✓ Q96DB2 1/20 0.33
HDAC8 known ✓ Q9BY41 1/20 0.33
HDAC6 known ✓ Q9UBN7 1/20 0.33
HDAC9 known ✓ Q9UKV0 1/20 0.33
HDAC5 known ✓ Q9UQL6 1/20 0.33
PARP1 known ✓ P09874 1/20 0.32
HPGD P15428 1/20 0.41
EPHX1 P07099 2/20 0.37
EPHX2 P34913 1/20 0.36
ALDH1A1 P00352 3/20 0.35
TSHR P16473 3/20 0.35
CES2 O00748 2/20 0.35
CES1 P23141 2/20 0.35
DAO P14920 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL11673314 1.00 HPGD (0.41) HPGDEPHX1EPHX2ALDH1A1TSHR
Water SCHEMBL1158114 0.97 HPGD (0.40) HPGDEPHX1EPHX2ALDH1A1TSHR
Water SCHEMBL459188 0.97 HPGD (0.40) HPGDEPHX1EPHX2ALDH1A1TSHR
Water SCHEMBL10833319 0.97 HPGD (0.40) HPGDEPHX1EPHX2ALDH1A1TSHR
SCHEMBL10663817 0.97 HPGD (0.43) HPGDEPHX1EPHX2ALDH1A1TSHR
SCHEMBL9175 0.97
SCHEMBL49328 0.97
SCHEMBL16674608 0.97
SCHEMBL1023085 0.94 HPGD (0.41) HPGDEPHX1EPHX2ALDH1A1TSHR
SCHEMBL7969703 0.94 HPGD (0.41) HPGDEPHX1EPHX2ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6855240-B2 CoFe alloy film and process of making same HITACHI GLOBAL STORAGE TECHNOLOGIES NETHERLANDS B.V. (NL) 2005-02-15 US claimed
US-20030209295-A1 CoFe alloy film and process of making same INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2003-11-13 US claimed
CN-104981427-A Fine copper nitride particles and production method therefor NAT INST OF ADVANCED IND SCIEN 2015-10-14 CN disclosed
US-8278243-B2 Laser imaging DATALASE LTD. (GB) 2012-10-02 US disclosed
EP-1704057-B1 LASER IMAGING DATALASE LTD (GB) 2011-03-30 EP disclosed
US-20100075848-A1 Laser Imaging DATALASE LTD. (GB) 2010-03-25 US disclosed
EP-1704057-A1 LASER IMAGING Sherwood Technology LTD. (GB) 2006-09-27 EP disclosed
WO-2005068207-A1 LASER IMAGING DATALASE LTD. (GB) 2005-07-28 WO disclosed
US-6855240-B2 CoFe alloy film and process of making same HITACHI GLOBAL STORAGE TECHNOLOGIES NETHERLANDS B.V. (NL) 2005-02-15 US disclosed
US-20030209295-A1 CoFe alloy film and process of making same INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2003-11-13 US disclosed