Water

Water

SCHEMBL459188

O.O.O=S(O)c1ccccc1.[NaH]

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 known ✓ O15379 1/20 0.32
HDAC4 known ✓ P56524 1/20 0.32
HDAC1 known ✓ Q13547 1/20 0.32
HDAC7 known ✓ Q8WUI4 1/20 0.32
HDAC2 known ✓ Q92769 1/20 0.32
HDAC10 known ✓ Q969S8 1/20 0.32
HDAC11 known ✓ Q96DB2 1/20 0.32
HDAC8 known ✓ Q9BY41 1/20 0.32
HDAC6 known ✓ Q9UBN7 1/20 0.32
HDAC9 known ✓ Q9UKV0 1/20 0.32
HDAC5 known ✓ Q9UQL6 1/20 0.32
PARP1 known ✓ P09874 1/20 0.31
HPGD P15428 1/20 0.40
EPHX1 P07099 2/20 0.35
EPHX2 P34913 1/20 0.35
ALDH1A1 P00352 3/20 0.33
TSHR P16473 3/20 0.33
CES2 O00748 2/20 0.33
CES1 P23141 2/20 0.33
DAO P14920 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL10833319 1.00 HPGD (0.40) HPGDEPHX1EPHX2ALDH1A1TSHR
Water SCHEMBL11673314 0.97 HPGD (0.41) HPGDEPHX1EPHX2ALDH1A1TSHR
SCHEMBL7969703 0.97 HPGD (0.41) HPGDEPHX1EPHX2ALDH1A1TSHR
SCHEMBL64469 0.97 HPGD (0.41) HPGDEPHX1EPHX2ALDH1A1TSHR
Water SCHEMBL1436264 0.97 HPGD (0.41) HPGDEPHX1EPHX2ALDH1A1TSHR
Water SCHEMBL1158114 0.94 HPGD (0.40) HPGDEPHX1EPHX2ALDH1A1TSHR
SCHEMBL8456563 0.94 HPGD (0.40) HPGDEPHX1EPHX2ALDH1A1TSHR
SCHEMBL49328 0.94
SCHEMBL9175 0.94
SCHEMBL16674608 0.94

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110878013-A Synthesis method of (trans ) -4-vinyl-4' - [ (E) -1-propenyl ] -bicyclohexane 西安瑞联新材料股份有限公司 2020-03-13 CN claimed
EP-1387659-B1 INITIATOR SYSTEM FOR ACID DENTAL FORMULATIONS 3M ESPE AG (DE) 2008-05-07 EP claimed
EP-4629958-A1 SURFACE-TREATED FILLER, DENTAL COMPOSITION CONTAINING SUCH A FILLER, PROCESS OF PRODUCTION AND USE THEREOF Solventum Intellectual Properties Company (US) 2025-10-15 EP disclosed
WO-2025032536-A1 1,3-DIAZA-4-OXA-[3.3.1]-BICYCLIC DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES, PARTICULARLY FOR THE TREATMENT OF OBESITY, DIABETES AND/OR NEURODEGENERATIVE DISEASES UNIVERSITÀ DI PISA (IT) 2025-02-13 WO disclosed
US-20240358603-A1 One-Part Dental Adhesive Composition for Fixing Dental Composite Materials SOLVENTUM INTELLECTUAL PROPERTIES COMPANY (US) 2024-10-31 US disclosed
US-12070514-B2 One-part dental adhesive composition for fixing dental composite materials SOLVENTUM INTELLECTUAL PROPERTIES COMPANY (US) 2024-08-27 US disclosed
EP-2598101-B2 KIT OF PARTS, METHOD OF PRODUCING AND USE THEREOF SOLVENTUM INTELLECTUAL PROPERTIES COMPANY (US) 2024-08-14 EP disclosed
US-20240245585-A1 Dental Cement Composition, Kit of Parts and Use Thereof SOLVENTUM INTELLECTUAL PROPERTIES COMPANY 2024-07-25 US disclosed
WO-2024121658-A1 SURFACE-TREATED FILLER, DENTAL COMPOSITION CONTAINING SUCH A FILLER, PROCESS OF PRODUCTION AND USE THEREOF SOLVENTUM INTELLECTUAL PROPERTIES COMPANY (US) 2024-06-13 WO disclosed
EP-4001888-B1 BIOLOGICAL TISSUE STAINING REAGENT, BIOLOGICAL TISSUE STAINING KIT AND BIOLOGICAL TISSUE STAINING METHOD CUBICSTARS INC (JP) 2023-10-04 EP disclosed
EP-4035649-B1 DENTAL ADHESIVE COMPOSITION 3M INNOVATIVE PROPERTIES COMPANY (US) 2023-07-26 EP disclosed
US-4999363-A Inhibit biosynthesis of thromboxane A2 KYOWA HAKKO KOGYO CO., LTD. (JP) 1991-03-12 US disclosed
EP-0194348-B1 SULFINATE-INITIATED ADDITION OF PERFLUORINATED IODIDES TO OLEFINS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1990-01-24 EP disclosed
EP-0345747-A2 Tricyclic compounds KYOWA HAKKO KOGYO CO., LTD. (JP) 1989-12-13 EP disclosed
US-4705737-A Heat developable photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1987-11-10 US disclosed
EP-0120403-B1 HEAT DEVELOPABLE COLOR PHOTOGRAPHIC MATERIALS FUJI PHOTO FILM CO., LTD. (JP) 1987-06-10 EP disclosed
US-4650913-A FLUOROALKYLATION, IODINATION E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-03-17 US disclosed
EP-0194348-A2 Sulfinate-initiated addition of perfluorinated iodides to olefins E.I. DU PONT DE NEMOURS AND COMPANY (US) 1986-09-17 EP disclosed
EP-0120403-A2 Heat developable color photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1984-10-03 EP disclosed
US-4102312-A Thermally developable light-sensitive materials TOYOTA JIDOSHA KOGYO KABUSHIKI KAISHA (JP) 1978-07-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240358603-A1 One-Part Dental Adhesive Composition for Fixing Dental Composite Materials CDH1, F12, ACTN1 HDAC3 2273/4885HDAC4 2373/4885HDAC1 435/4885
US-20240245585-A1 Dental Cement Composition, Kit of Parts and Use Thereof CAD, KATNAL2, ASH2L HDAC3 2195/4885HDAC4 3307/4885HDAC1 2013/4885
US-12070514-B2 One-part dental adhesive composition for fixing dental composite materials CDH1, F12, ACTN1 HDAC3 2273/4885HDAC4 2373/4885HDAC1 435/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.