SCHEMBL14366249

SCHEMBL14366249

CCCC1CCC(c2ccc(O)cc2)OC1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FASN P49327 1/20 0.46
ESR2 Q92731 10/20 0.41
SHBG P04278 1/20 0.40
ESR1 P03372 8/20 0.40
CYP2C9 P11712 3/20 0.40
CYP3A4 P08684 2/20 0.40
ALOX5 P09917 1/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
MAPT P10636 1/20 0.38
MEN1 O00255 1/20 0.38
MAPK1 P28482 1/20 0.38
KMT2A Q03164 1/20 0.38
CYP2D6 P10635 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10550395 0.90 FASN (0.39) FASNESR2SHBGESR1CYP2C9
SCHEMBL10552694 0.86 FASN (0.44) FASNCYP2C9CYP3A4ALDH1A1LMNA
SCHEMBL10551160 0.86 FASN (0.44) FASNCYP2C9ALDH1A1LMNAMAPT
SCHEMBL16591212 0.86 FASN (0.44) FASNCYP2C9CYP3A4ALDH1A1LMNA
SCHEMBL14313761 0.84 ESR2 (0.41) FASNESR2ESR1CYP2C9CYP3A4
SCHEMBL10550846 0.84 SLC6A3 (0.43) FASNCYP2C9ALDH1A1LMNAMAPT
SCHEMBL10551733 0.84 FASN (0.43) FASNCYP2C9ALDH1A1LMNAMAPT
SCHEMBL10555297 0.84 FASN (0.43) FASNCYP2C9ALDH1A1LMNAMAPT
SCHEMBL10550706 0.84 TSHR (0.52) FASN
SCHEMBL14366247 0.84 FASN (0.44) FASNCYP2C9ALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4100489-B1 LIQUID-CRYSTALLINE COMPOUNDS MERCK PATENT GMBH (DE) 2024-01-10 EP disclosed
EP-3712230-B1 LIQUID CRYSTAL COMPOUNDS MERCK PATENT GMBH (DE) 2023-05-17 EP disclosed
EP-3712230-B1 LIQUID CRYSTAL COMPOUNDS MERCK PATENT GMBH (DE) 2023-05-17 EP disclosed
EP-4100489-A1 LIQUID-CRYSTALLINE COMPOUNDS Merck Patent GmbH (DE) 2022-12-14 EP disclosed
US-11208595-B2 Liquid-crystalline compounds MERCK PATENT GMBH (DE) 2021-12-28 US disclosed
US-11208595-B2 Liquid-crystalline compounds MERCK PATENT GMBH (DE) 2021-12-28 US disclosed
WO-2021156232-A1 LIQUID-CRYSTALLINE COMPOUNDS MERCK PATENT GMBH (DE) 2021-08-12 WO disclosed
WO-2021156232-A1 LIQUID-CRYSTALLINE COMPOUNDS MERCK PATENT GMBH (DE) 2021-08-12 WO disclosed
US-20200299580-A1 LIQUID-CRYSTALLINE COMPOUNDS MERCK PATENT GMBH (DE) 2020-09-24 US disclosed
US-20200299580-A1 LIQUID-CRYSTALLINE COMPOUNDS MERCK PATENT GMBH (DE) 2020-09-24 US disclosed
US-9951277-B2 Liquid crystal compound having 1,1,3,3-tetrafluoroallyloxy group, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2018-04-24 US disclosed
EP-3135659-A1 LIQUID CRYSTAL COMPOUND HAVING 1,1,3,3-TETRAFLUOROALLYLOXY GROUP, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT JNC Corporation (JP) 2017-03-01 EP disclosed
EP-3135659-A1 LIQUID CRYSTAL COMPOUND HAVING 1,1,3,3-TETRAFLUOROALLYLOXY GROUP, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT JNC Corporation (JP) 2017-03-01 EP disclosed
US-20160362605-A1 LIQUID CRYSTAL COMPOUND HAVING 1,1,3,3-TETRAFLUOROALLYLOXY GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2016-12-15 US disclosed
US-20160362605-A1 LIQUID CRYSTAL COMPOUND HAVING 1,1,3,3-TETRAFLUOROALLYLOXY GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2016-12-15 US disclosed
US-20160362605-A1 LIQUID CRYSTAL COMPOUND HAVING 1,1,3,3-TETRAFLUOROALLYLOXY GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2016-12-15 US disclosed
WO-2015129540-A1 LIQUID CRYSTAL COMPOUND HAVING 1,1,3,3-TETRAFLUOROALLYLOXY GROUP, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT JNC株式会社 2015-09-03 WO disclosed
US-7291367-B2 Liquid-crystalline compounds MERCK PATENT GMBH (DE) 2007-11-06 US disclosed
US-7291367-B2 Liquid-crystalline compounds MERCK PATENT GMBH (DE) 2007-11-06 US disclosed
EP-1482021-B1 Pyrans as liquid crystals MERCK PATENT GMBH (DE) 2007-01-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11208595-B2 Liquid-crystalline compounds CHRM1, C1S, CHRM2 FASN 2128/4885ESR2 1275/4885SHBG 615/4885
US-20160362605-A1 LIQUID CRYSTAL COMPOUND HAVING 1,1,3,3-TETRAFLUOROALLYLOXY GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE TCOF1, PIEZO1, RCC1 FASN 3041/4885ESR2 3156/4885SHBG 4379/4885
US-20200299580-A1 LIQUID-CRYSTALLINE COMPOUNDS CHRM1, C1S, CHRM2 FASN 2128/4885ESR2 1275/4885SHBG 615/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.