SCHEMBL143839

SCHEMBL143839

COc1c(CC=C(C)C)c(O)c(CC=C(C)C)c(O)c1C(=O)/C=C/c1ccc(O)cc1

nearest known ligand 0.69

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.69
TTR P02766 1/20 0.69
ALOX5 P09917 1/20 0.69
MEN1 O00255 1/20 0.62
LMNA P02545 1/20 0.62
MAPT P10636 1/20 0.62
MAOB P27338 1/20 0.62
KMT2A Q03164 1/20 0.62
ABCB1 P08183 13/20 0.60
PTPN1 P18031 3/20 0.58
DHODH Q02127 1/20 0.58
MGAM O43451 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12961706 0.91 PDPK1 (0.61) PDPK1TTRALOX5MEN1LMNA
SCHEMBL4834258 0.90 PDPK1 (0.63) PDPK1TTRALOX5MEN1LMNA
SCHEMBL4834251 0.90 PDPK1 (0.63) PDPK1TTRALOX5MEN1LMNA
SCHEMBL144848 0.83 ABCB1 (0.85) PDPK1TTRALOX5MEN1LMNA
Xanthohumol SCHEMBL738122 0.82 PDPK1 (1.00) PDPK1TTRALOX5MEN1LMNA
Xanthogalenol SCHEMBL30259154 0.82 PDPK1 (0.84) PDPK1TTRALOX5MEN1LMNA
Xanthohumol SCHEMBL143683 0.82 PDPK1 (1.00) PDPK1TTRALOX5MEN1LMNA
Xanthogalenol SCHEMBL4837290 0.82 PDPK1 (0.84) PDPK1TTRALOX5MEN1LMNA
Xanthohumol SCHEMBL30169731 0.82 PDPK1 (1.00) PDPK1TTRALOX5MEN1LMNA
Xanthogalenol SCHEMBL4837282 0.82 PDPK1 (0.84) PDPK1TTRALOX5MEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190046469-A1 COMPOSITIONS AND METHODS FOR TREATING MOOD DISORDERS OR SKIN DISEASE OR DAMAGE KUHRTS ERIC HAUSER (US) 2019-02-14 US claimed
US-20150283098-A1 PRENYLATED CHALCONE FORMULATION FOR THE TREATMENT OF BEES BIOACTIVE-TECH SP Z.O.O. (PL) 2015-10-08 US claimed
EP-2908634-A1 PRENYLATED CHALCONE FORMULATION FOR THE TREATMENT OF BEES Bioactive-tech Sp. z z.o. (PL) 2015-08-26 EP claimed
US-20150209307-A1 COMPOSITIONS AND METHODS FOR TREATING MOOD DISORDERS OR SKIN DISEASE OR DAMAGE KUHRTS ERIC HAUSER (US) 2015-07-30 US claimed
WO-2014060803-A1 PRENYLATED CHALCONE FORMULATION FOR THE TREATMENT OF BEES BIOACTIVE-TECH SP. Z O.O. (PL) 2014-04-24 WO claimed
US-20140045904-A1 NIACIN FORMULATIONS AND METHODS WITH REDUCED FLUSHING SIDE EFFECT KUHRTS ERIC HAUSER (US) 2014-02-13 US claimed
WO-2014025989-A1 COMPOSITIONS AND METHODS FOR TREATING MOOD DISORDERS OR SKIN DISEASE OR DAMAGE KUHRTS ERIC HAUSER (US) 2014-02-13 WO claimed
WO-2012051107-A2 NIACIN FORMULATIONS AND METHODS WITH REDUCED FLUSHING SIDE-EFFECT KUHRTS ERIC HAUSER (US) 2012-04-19 WO claimed
US-20120059052-A1 PRENYLFLAVONOID FORMULATIONS BIOACTIVES, INC. (US) 2012-03-08 US claimed
US-20110207697-A1 XANTHOHUMOL COMPOSITIONS AND METHODS FOR TREATING SKIN DISEASES OR DISORDERS BETAL, LLC (US) 2011-08-25 US claimed
US-20110003888-A1 HOPS EXTRACTION METHODS AND MIXTURES BIOACTIVES, INC. (US) 2011-01-06 US claimed
EP-2249641-A1 NOVEL COMPOSITIONS CONTAINING XANTHOHUMOL-CYCLODEXTRIN COMPLEXES Flaxan GmbH & Co. KG (US) 2010-11-17 EP claimed
WO-2009126320-A1 XANTHOHUMOL COMPOSITIONS AND METHODS FOR TREATING SKIN DISEASES OR DISORDERS BETAL, LLC (US) 2009-10-15 WO claimed
WO-2009108379-A1 NOVEL COMPOSITIONS CONTAINING XANTHOHUMOL-CYCLODEXTRIN COMPLEXES FLAXAN GMBH & CO. KG (US) 2009-09-03 WO claimed
US-20090209654-A1 Prenylflavonoid Formulations BIOACTIVES, INC. 2009-08-20 US claimed
WO-2008095189-A1 METHODS AND COMPOSITIONS FOR TREATING DYSLIPIDAEMIA BIOACTIVES, INC. (US) 2008-08-07 WO claimed
WO-2008089137-A1 HOPS EXTRACTION METHODS AND MIXTURES BIOACTIVES, INC. (US) 2008-07-24 WO claimed
EP-1909584-A2 PRENYLFLAVONOID FORMULATIONS Bioactives, Inc. (US) 2008-04-16 EP claimed
US-20070218155-A1 Methods and compositions for treating dyslipidaemia BIOACTIVES, INC. 2007-09-20 US claimed
WO-2007016578-A2 PRENYLFLAVONOID FORMULATIONS BIOACTIVES, INC. (US) 2007-02-08 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150283098-A1 PRENYLATED CHALCONE FORMULATION FOR THE TREATMENT OF BEES API5, CYP51A1, CYP46A1 PDPK1 969/4885TTR 2530/4885ALOX5 1990/4885
US-20120059052-A1 PRENYLFLAVONOID FORMULATIONS TP53, CYP46A1, HPGD PDPK1 1418/4885TTR 542/4885ALOX5 837/4885
US-20150209307-A1 COMPOSITIONS AND METHODS FOR TREATING MOOD DISORDERS OR SKIN DISEASE OR DAMAGE CUTA, PSEN2, PNN PDPK1 1218/4885TTR 470/4885ALOX5 2680/4885
US-20190046469-A1 COMPOSITIONS AND METHODS FOR TREATING MOOD DISORDERS OR SKIN DISEASE OR DAMAGE CUTA, PSEN2, PNN PDPK1 1218/4885TTR 470/4885ALOX5 2680/4885
US-20110003888-A1 HOPS EXTRACTION METHODS AND MIXTURES HMGB2, HMGB3, HPGDS PDPK1 2732/4885TTR 1767/4885ALOX5 3761/4885
US-20140045904-A1 NIACIN FORMULATIONS AND METHODS WITH REDUCED FLUSHING SIDE EFFECT NAPRT, NISCH, NAMPT PDPK1 3203/4885TTR 274/4885ALOX5 102/4885
US-20090209654-A1 Prenylflavonoid Formulations TP53, CYP46A1, HPGD PDPK1 1418/4885TTR 542/4885ALOX5 837/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.