Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 5/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.30 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.30 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.30 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18894087 | 0.62 | RORC (0.30) | — | |
| SCHEMBL7812114 | 0.60 | PDE2A (0.38) | PDE2A | |
| SCHEMBL18894119 | 0.60 | HSD11B1 (0.30) | — | |
| SCHEMBL5540266 | 0.59 | PTGS2 (0.35) | TDP1 | |
| SCHEMBL28700769 | 0.59 | TDP1 (0.40) | BRAFNOTUMTDP1 | |
| SCHEMBL3651143 | 0.58 | PKM (0.50) | PDE2APKM | |
| SCHEMBL171040 | 0.57 | PDE2A (0.50) | PDE2AMCL1 | |
| SCHEMBL19120598 | 0.57 | NPBWR1 (0.49) | NPBWR1MCHR1BRAF | |
| SCHEMBL3280154 | 0.57 | POLB (0.37) | PKM | |
| SCHEMBL6151773 | 0.56 | NOTUM (0.44) | BRAFNOTUMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |