Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.53 |
| ▸ | CCR5 | P51681 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 3/20 | 0.51 |
| ▸ | CA4 | P22748 | 3/20 | 0.51 |
| ▸ | CA6 | P23280 | 3/20 | 0.51 |
| ▸ | CA5A | P35218 | 3/20 | 0.51 |
| ▸ | CA7 | P43166 | 3/20 | 0.51 |
| ▸ | CA9 | Q16790 | 3/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.51 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | MMP1 | P03956 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MMP9 | P14780 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 5/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13310702 | 0.87 | CA12 (0.53) | IAPPCCR5PTGS1CA12CA4 | |
| SCHEMBL8848008 | 0.80 | IAPP (0.67) | IAPPCCR5PTGS1CA12CA4 | |
| SCHEMBL9683152 | 0.80 | IAPP (0.67) | IAPPCCR5PTGS1CA12CA4 | |
| SCHEMBL1976133 | 0.79 | IAPP (0.66) | IAPPCCR5CA12CA4CA6 | |
| SCHEMBL1976131 | 0.79 | IAPP (0.66) | IAPPCCR5CA12CA4CA6 | |
| SCHEMBL21998520 | 0.78 | AKR1B10 (0.67) | CA12CA4CA6CA5ACA7 | |
| SCHEMBL4545217 | 0.77 | ALOX5 (0.67) | IAPPCCR5PTGS1CA12CA4 | |
| SCHEMBL30449722 | 0.77 | ALOX5 (0.67) | IAPPCCR5PTGS1CA12CA4 | |
| SCHEMBL29565226 | 0.76 | HTR1A (0.69) | PTGS1CA12CA4CA6CA5A | |
| SCHEMBL13310700 | 0.76 | GSK3B (0.58) | CA12CA4CA6CA5ACA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282523-B2 | Pharmaceutical compositions useful in prevention and treatment of beta-amyloid protein-induced disease | KIM DARRICK S H L | 2007-10-16 | — | — | US | disclosed |