Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ACLY | P53396 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23554954 | 0.84 | KEAP1 (0.62) | ALDH1A1MAPK1PTK2BKMT2APGR | |
| SCHEMBL10884855 | 0.82 | KDM4E (0.59) | ALDH1A1KDM4EHPGDGLO1CA1 | |
| SCHEMBL13853042 | 0.81 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDGLO1MAPK1 | |
| SCHEMBL14818627 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDGLO1MAPK1 | |
| SCHEMBL12962542 | 0.81 | PSIP1 (0.63) | ALDH1A1PARP14 | |
| SCHEMBL23555113 | 0.81 | PARP14 (0.57) | ALDH1A1KDM4EHPGDGLO1MAPK1 | |
| SCHEMBL14818773 | 0.81 | GLO1 (0.52) | ALDH1A1KDM4EHPGDGLO1MAPK1 | |
| SCHEMBL13852845 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDMAPK1PTK2B | |
| SCHEMBL7589006 | 0.79 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDGLO1MAPK1 | |
| SCHEMBL31615866 | 0.79 | HPGD (0.55) | ALDH1A1KDM4EHPGDMAPK1PTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| US-20140235616-A1 | PYRAZOLOQUINOLINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2014-08-21 | — | — | US | disclosed |
| WO-2013056163-A1 | BETA-LACTAMASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-04-18 | — | — | WO | disclosed |
| WO-2007112998-A1 | 3-UNSUBSTITUTED N-(ARYL- OR HETEROARVL)-PYRAZOLORI [1,5-A]PYRIMIDINES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235616-A1 | PYRAZOLOQUINOLINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | CYP11B2, CYP1A2, COQ8A | ALDH1A1 97/4885KDM4E 3756/4885HPGD 274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.