Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 13/20 | 0.48 |
| ▸ | MMP9 | P14780 | 11/20 | 0.48 |
| ▸ | MMP2 | P08253 | 10/20 | 0.48 |
| ▸ | MMP12 | P39900 | 8/20 | 0.48 |
| ▸ | MMP14 | P50281 | 8/20 | 0.48 |
| ▸ | MMP15 | P51511 | 7/20 | 0.48 |
| ▸ | MMP16 | P51512 | 7/20 | 0.48 |
| ▸ | MMP26 | Q9NRE1 | 7/20 | 0.48 |
| ▸ | MMP7 | P09237 | 7/20 | 0.48 |
| ▸ | MMP3 | P08254 | 7/20 | 0.44 |
| ▸ | MMP8 | P22894 | 3/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14427297 | 0.91 | MMP1 (0.48) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL14427211 | 0.90 | PSEN1 (0.42) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL14427212 | 0.88 | MMP2 (0.47) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL14427239 | 0.81 | MMP1 (0.51) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL14427197 | 0.79 | MMP12 (0.69) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL14427235 | 0.77 | MMP3 (0.45) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL14427213 | 0.77 | PSEN1 (0.42) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL5163129 | 0.76 | MMP3 (0.41) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL5162221 | 0.76 | MMP8 (0.42) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL14427247 | 0.75 | MMP2 (0.52) | MMP1MMP9MMP2MMP12MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203118-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-30 | — | — | US | disclosed |
| US-20070203118-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203118-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS | MMP9, MMP2, MMP3 | MMP1 8/4885MMP9 1/4885MMP2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.