SCHEMBL144609

SCHEMBL144609

O=C(Cl)c1ccc2c(c1)OCO2

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.69
MAPK1 P28482 1/20 0.69
SRD5A2 P31213 1/20 0.61
MEN1 O00255 4/20 0.59
KMT2A Q03164 4/20 0.59
HPGD P15428 4/20 0.57
NPC1 O15118 4/20 0.57
RAB9A P51151 4/20 0.57
SMN1; SMN2 Q16637 3/20 0.57
NFKB1 P19838 2/20 0.57
NFKB2 Q00653 2/20 0.57
RELA Q04206 2/20 0.57
PKM P14618 2/20 0.57
MAPT P10636 1/20 0.57
CYP1A2 P05177 1/20 0.56
CYP3A4 P08684 1/20 0.56
CYP2D6 P10635 1/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
CTNNB1 P35222 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL828491 0.88 TSHR (0.67) MAPK1HPGDNPC1RAB9ASMN1; SMN2
SCHEMBL1189145 0.85 NPC1 (0.63) ALDH1A1MAPK1MEN1KMT2AHPGD
SCHEMBL4824941 0.83 SRD5A2 (0.82) ALDH1A1MAPK1SRD5A2MEN1KMT2A
SCHEMBL28705388 0.83 ALDH1A1 (0.62) ALDH1A1MAPK1SRD5A2MEN1KMT2A
SCHEMBL2601929 0.83 ALDH1A1 (0.74) ALDH1A1MAPK1SRD5A2MEN1KMT2A
SCHEMBL18101244 0.83 KDM4E (0.70) ALDH1A1KMT2AHPGDNPC1RAB9A
SCHEMBL18101284 0.83 KDM4E (0.70) ALDH1A1KMT2AHPGDNPC1RAB9A
SCHEMBL18101240 0.83 KDM4E (0.70) ALDH1A1KMT2AHPGDNPC1RAB9A
SCHEMBL18101248 0.83 KDM4E (0.70) ALDH1A1KMT2AHPGDNPC1RAB9A
SCHEMBL10441519 0.82 MEN1 (0.61) ALDH1A1MAPK1SRD5A2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 837 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12552931-B2 Dihydroxy lactam based polymers, compositions and applications thereof ISP INVESTMENTS LLC (US) 2026-02-17 US claimed
US-20220315761-A1 DIHYDROXY LACTAM BASED POLYMERS, COMPOSITIONS AND APPLICATIONS THEREOF ISP INVESTMENTS LLC (US) 2022-10-06 US claimed
CN-101775084-B Method for preparing organic-dissolvable photosensitive chitosan derivate CHANGZHOU INST OF ADVANCED MATERIALS BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY 2011-11-09 CN claimed
CN-101781375-A Preparation method of organic soluble photosensitive chitosan derivative CHANGZHOU INST OF ADVANCED MAT 2010-07-21 CN claimed
CN-101775084-A Method for preparing organic-dissolvable photosensitive chitosan derivate UNIV BEIJING CHEMICAL 2010-07-14 CN claimed
US-20070202612-A1 Plasma-Polymerisation Of Polycylic Compounds FORSKININGSCENTER RISO 2007-08-30 US claimed
WO-2005092521-A2 PLASMA-POLYMERISATION OF POLYCYCLIC COMPOUNDS Forskningscenter Risø (DK) 2005-10-06 WO claimed
EP-4713018-A1 TRANSFECTION COMPOSITIONS SUITABLE FOR PRODUCING A BIOLOGICAL PRODUCT PolyPlus Transfection (FR) 2026-03-25 EP disclosed
US-12552931-B2 Dihydroxy lactam based polymers, compositions and applications thereof ISP INVESTMENTS LLC (US) 2026-02-17 US disclosed
US-12384778-B2 Pyrazolopyridine compounds and uses thereof INCYTE CORPORATION (US) 2025-08-12 US disclosed
WO-2025098545-A1 NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST CORONAVIRUSES USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I. (CZ) 2025-05-15 WO disclosed
EP-4553080-A1 NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST CORONAVIRUSES Ustav Organicke Chemie a Biochemie AV CR, v.v.i. (CZ) 2025-05-14 EP disclosed
US-20250057802-A1 BROAD-SPECTRUM ANTIVIRAL DRUGS Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2025-02-20 US disclosed
EP-0058435-A2 Novel 4-aroylimidazol-2-ones MERRELL DOW PHARMACEUTICALS INC. (US) 1982-08-25 EP disclosed
US-4325873-A Process for the preparation of styryl-cyclopropanecarboxylic acid esters and intermediate products for this process BAYER AKTIENGESELLSCHAFT (DE) 1982-04-20 US disclosed
US-4267174-A AND PROCESS FOR ADMINISTERING BOEHRINGER MANNHEIM, GMBH (DE) 1981-05-12 US disclosed
US-4260774-A IMMUNOSUPPRESSANTS, ANTITUMOR SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1981-04-07 US disclosed
EP-0018531-A1 Substituted 2,2-dimethylpentane (ene)-1-carboxylic acid derivatives, process for their preparation and their use for the preparation of styryl-cyclopropane-carboxylates BAYER AG (DE) 1980-11-12 EP disclosed
US-4009208-A N,N'-HEPTAMETHYLENEBIS(4-METHOXYBENZAMIDE) STERLING DRUG INC. (US) 1977-02-22 US disclosed
US-3987059-A ALKYL LITHIUM, CYCLIZATION, DEMETALLIZATION SANDOZ, INC. (US) 1976-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12384778-B2 Pyrazolopyridine compounds and uses thereof PDXK, PCK1, PGK1 ALDH1A1 2205/4885MAPK1 639/4885SRD5A2 1333/4885
US-20250057802-A1 BROAD-SPECTRUM ANTIVIRAL DRUGS MAVS, EIF2AK2, ZC3HAV1 ALDH1A1 3273/4885MAPK1 4668/4885SRD5A2 3429/4885
US-12552931-B2 Dihydroxy lactam based polymers, compositions and applications thereof PARG, GNE, PGLS ALDH1A1 235/4885MAPK1 4476/4885SRD5A2 1283/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.