Sugi Predict

Sugi Predict / Compounds / SCHEMBL1449523

SCHEMBL1449523

SCHEMBL1449523

Cn1nnnc1CC(=O)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ HSD11B1 P28845 10/20 0.49
▸ HPGD P15428 2/20 0.47
▸ ALDH1A1 P00352 2/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ DAGLA Q9Y4D2 1/20 0.43
▸ PTPN1 P18031 1/20 0.43
▸ GSK3B P49841 1/20 0.43
▸ MGAM O43451 1/20 0.43
▸ AMY1A P0DUB6 1/20 0.43
▸ GAA P10253 1/20 0.43
▸ SI P14410 1/20 0.43
▸ MGAM2 Q2M2H8 1/20 0.43
▸ LMNA P02545 1/20 0.42
▸ TSHR P16473 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ KDM4E B2RXH2 1/20 0.41
▸ GLA P06280 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2205869 0.84 LMNA (0.47) ALDH1A1SMN1; SMN2GSK3BMGAMAMY1A
SCHEMBL10753556 0.79 POLB (0.40) HSD11B1HPGDALDH1A1DAGLAGAA
SCHEMBL2182851 0.78 DAGLA (0.65) HSD11B1ALDH1A1DAGLA
SCHEMBL5504671 0.75 HSD11B1 (0.46) HSD11B1HPGDALDH1A1SMN1; SMN2MGAM
SCHEMBL10973099 0.74 ALDH1A1 (0.67) ALDH1A1SMN1; SMN2GAALMNATSHR
SCHEMBL10972843 0.72 HSD17B10 (0.56) HSD11B1ALDH1A1SMN1; SMN2GAALMNA
SCHEMBL10546284 0.72 ALDH1A1 (0.35) HPGDALDH1A1DAGLAGAALMNA
SCHEMBL242834 0.71 HIF1A (0.45) HSD11B1ALDH1A1SMN1; SMN2GAARAB9A
SCHEMBL10952972 0.71 KMT2A (0.51) HPGDALDH1A1SMN1; SMN2TSHRRAB9A
SCHEMBL16618386 0.71 HPGD (0.47) HSD11B1HPGDSMN1; SMN2MGAMAMY1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3221305-B1 METHOD FOR PREPARATION OF CERTAIN 1,5 DISUBSTITUTED TETRAZOLES LONZA AG (CH) 2018-03-07 — — EP disclosed
EP-1794157-B1 2-ACYLAMINOTHIAZOLE DERIVATIVES LUNDBECK & CO AS H (DK) 2014-02-26 — — EP disclosed
EP-1794157-B1 2-ACYLAMINOTHIAZOLE DERIVATIVES LUNDBECK & CO AS H (DK) 2014-02-26 — — EP disclosed
US-7910613-B2 2-acylaminothiazole derivatives H. LUNDBECK A/S (DK) 2011-03-22 — — US disclosed
US-7910613-B2 2-acylaminothiazole derivatives H. LUNDBECK A/S (DK) 2011-03-22 — — US disclosed
US-7910613-B2 2-acylaminothiazole derivatives H. LUNDBECK A/S (DK) 2011-03-22 — — US disclosed
US-20090137642-A1 2-Acylaminothiazole Derivatives H. LUNDBECK A/S (DK) 2009-05-28 — — US disclosed
US-20090137642-A1 2-Acylaminothiazole Derivatives H. LUNDBECK A/S (DK) 2009-05-28 — — US disclosed
US-20090137642-A1 2-Acylaminothiazole Derivatives H. LUNDBECK A/S (DK) 2009-05-28 — — US disclosed
EP-1794157-A1 2-ACYLAMINOTHIAZOLE DERIVATIVES H.Lundbeck A/S (DK) 2007-06-13 — — EP disclosed
WO-2006032273-A1 2-ACYLAMINOTHIAZOLE DERIVATIVES H. LUNDBECK A/S (DK) 2006-03-30 — — WO disclosed
WO-2006032273-A1 2-ACYLAMINOTHIAZOLE DERIVATIVES H. LUNDBECK A/S (DK) 2006-03-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137642-A1 2-Acylaminothiazole Derivatives ADORA2A, HTR2C, ADORA2B HSD11B1 2626/4885HPGD 2020/4885ALDH1A1 446/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.