SCHEMBL145897

SCHEMBL145897

O=C(c1cc(Br)ccc1O)c1ccccc1Cl

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSTA1 P08263 4/20 0.75
CYP1A2 P05177 2/20 0.70
CYP2C9 P11712 2/20 0.70
CYP2C19 P33261 2/20 0.70
HPGD P15428 1/20 0.70
ALOX15 P16050 1/20 0.70
CASP1 P29466 1/20 0.70
MAPT P10636 3/20 0.58
TP53 P04637 1/20 0.56
CES2 O00748 2/20 0.55
GALR3 O60755 1/20 0.55
MAPK1 P28482 1/20 0.54
KDM4E B2RXH2 2/20 0.52
LMNA P02545 2/20 0.52
KMT2A Q03164 2/20 0.52
ALOX12 P18054 1/20 0.52
HTT P42858 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
ADCY10 Q96PN6 1/20 0.49
CYP2D6 P10635 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15684683 0.84 ALOX15 (1.00) GSTA1CYP1A2CYP2C9CYP2C19HPGD
SCHEMBL332634 0.83 RECQL (0.71) GSTA1CYP1A2CYP2C9CYP2C19HPGD
SCHEMBL31315936 0.83 RECQL (0.71) GSTA1CYP1A2CYP2C9CYP2C19HPGD
SCHEMBL11843932 0.83 RECQL (0.51) GSTA1CYP1A2CYP2C19HPGDALOX15
SCHEMBL145258 0.83 RECQL (0.70) GSTA1CYP1A2CYP2C19HPGDALOX15
SCHEMBL21812547 0.81 GSTA1 (0.77) GSTA1CYP1A2CYP2C9CYP2C19HPGD
SCHEMBL8201650 0.80 RECQL (0.49) GSTA1MAPTTP53CES2MAPK1
SCHEMBL144475 0.80 KMT2A (0.70) GSTA1CYP1A2CYP2C19HPGDMAPT
SCHEMBL2924890 0.80 CES2 (0.58) GSTA1CYP1A2CYP2C19HPGDALOX15
SCHEMBL9712400 0.80 MAPT (0.54) GSTA1CYP1A2CYP2C9CYP2C19HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2613819-B2 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD (GB) 2020-11-25 EP claimed
EP-2613819-B1 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD (GB) 2018-01-10 EP claimed
CN-103209717-B Lubricious coatings for medical devices BIOINTERACTIONS LTD 2015-04-08 CN claimed
US-8541498-B2 Lubricious coatings for medical devices BIOINTERACTIONS LTD. (GB) 2013-09-24 US claimed
EP-2613819-A1 Lubricious coatings for medical devices Biointeractions Ltd. (GB) 2013-07-17 EP claimed
WO-2012032283-A1 Lubricious coatings for medical devices BIOINTERACTIONS LTD (GB) 2012-03-15 WO claimed
US-20120059111-A1 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD. (GB) 2012-03-08 US claimed
CN-114805133-A Aryl chloroformate preparation method 苏州星日化学有限公司 2022-07-29 CN disclosed
EP-2613819-B2 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD (GB) 2020-11-25 EP disclosed
EP-2613819-B1 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD (GB) 2018-01-10 EP disclosed
US-8541498-B2 Lubricious coatings for medical devices BIOINTERACTIONS LTD. (GB) 2013-09-24 US disclosed
EP-2613819-A1 Lubricious coatings for medical devices Biointeractions Ltd. (GB) 2013-07-17 EP disclosed
WO-2012032283-A1 Lubricious coatings for medical devices BIOINTERACTIONS LTD (GB) 2012-03-15 WO disclosed
US-20120059111-A1 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD. (GB) 2012-03-08 US disclosed