Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | DBH | P09172 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32683807 | 0.80 | CYP11B1 (0.59) | CYP11B1CYP11B2DBHIDO1SLC2A1 | |
| SCHEMBL15358325 | 0.76 | IDO1 (0.57) | CYP11B1CYP11B2CDK9IDO1HPGDS | |
| SCHEMBL10644152 | 0.72 | L3MBTL1 (0.50) | CYP11B1CYP11B2L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1460580 | 0.70 | ALDH1A1 (0.58) | CYP11B1CYP11B2L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4179745 | 0.69 | CYP11B1 (0.65) | CYP11B1CYP11B2L3MBTL1DBHALDH1A1 | |
| SCHEMBL11015789 | 0.69 | ADORA2A (0.71) | — | |
| SCHEMBL21121839 | 0.69 | L3MBTL1 (0.44) | CYP11B1CYP11B2L3MBTL1DBHCDK9 | |
| SCHEMBL7974168 | 0.69 | CDK9 (0.45) | CYP11B1CYP11B2L3MBTL1CDK9ALDH1A1 | |
| SCHEMBL3616273 | 0.69 | MAPT (0.65) | CYP11B1CYP11B2L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL10721034 | 0.69 | CYP11B1 (0.48) | CYP11B1CYP11B2L3MBTL1DBHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473509-A1 | KINASE INHIBITORS, PRODRUG FORMS THEREOF AND THEIR USE IN THERAPY | Auckland UniServices Limited (NZ) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011028135-A1 | KINASE INHIBITORS, PRODRUG FORMS THEREOF AND THEIR USE IN THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2011-03-10 | — | — | WO | disclosed |