Sugi Predict

Sugi Predict / Compounds / SCHEMBL1462002

SCHEMBL1462002

SCHEMBL1462002

O=C(Cl)Cc1ccc(OC(F)(F)F)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NLRP3 Q96P20 1/20 0.50
▸ EPHX2 P34913 3/20 0.49
▸ LTA4H P09960 1/20 0.49
▸ HRH3 Q9Y5N1 2/20 0.48
▸ MAPK8 P45983 1/20 0.48
▸ MEN1 O00255 1/20 0.48
▸ KMT2A Q03164 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48
▸ CACNA1G O43497 1/20 0.46
▸ CACNA1H O95180 1/20 0.46
▸ CACNA1I Q9P0X4 1/20 0.46
▸ PANK3 Q9H999 1/20 0.46
▸ EPHX1 P07099 2/20 0.46
▸ NR1H4 Q96RI1 1/20 0.46
▸ ALDH1A1 P00352 1/20 0.45
▸ TSHR P16473 1/20 0.45
▸ TRPV1 Q8NER1 1/20 0.45
▸ VNN1 O95497 1/20 0.44
▸ BCL2L1 Q07817 1/20 0.44
▸ MRGPRX4 Q96LA9 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL378766 0.83 EPHX2 (0.54) NLRP3EPHX2LTA4HHRH3MAPK8
SCHEMBL2251955 0.82 VNN1 (0.51) NLRP3EPHX2LTA4HHRH3MAPK8
SCHEMBL11172641 0.82 POLB (0.41) EPHX2HRH3MEN1KMT2ASMN1; SMN2
SCHEMBL328546 0.81 MAPK8 (0.55) NLRP3EPHX2LTA4HMAPK8EPHX1
SCHEMBL7983265 0.81 POLB (0.56) NLRP3EPHX2LTA4HHRH3MAPK8
Hydrochloric Acid SCHEMBL1373117 0.81 EPHX2 (0.52) NLRP3EPHX2LTA4HHRH3MAPK8
SCHEMBL31264426 0.80 EPHX2 (0.51) NLRP3EPHX2LTA4HHRH3MAPK8
SCHEMBL22816202 0.80 VNN1 (0.49) NLRP3EPHX2LTA4HHRH3MAPK8
SCHEMBL1792094 0.80 CNR1 (0.50) EPHX1VNN1MRGPRX4
SCHEMBL12731531 0.79 VNN1 (0.48) NLRP3EPHX2LTA4HHRH3MAPK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250333902-A1 FLUORINE-CONTAINING COMPOUND DAIKIN INDUSTRIES, LTD. (JP) 2025-10-30 — — US disclosed
EP-4516773-A1 FLUORINE-CONTAINING COMPOUND DAIKIN INDUSTRIES, LTD. (JP) 2025-03-05 — — EP disclosed
CN-119039261-A Epigenetic medicine for enhancing anticancer effect of platinum antitumor agent and application thereof 山东铂源药业股份有限公司 2024-11-29 — — CN disclosed
WO-2024185687-A1 FLUORINE-CONTAINING COMPOUND ダイキン工業株式会社 2024-09-12 — — WO disclosed
US-20220372033-A1 ANTIBACTERIAL COMPOUNDS Janssen Sciences Ireland Unlimited Company (IE) 2022-11-24 — — US disclosed
CN-110036014-B Compound with AXL inhibitory activity and preparation and application thereof 中国科学院上海药物研究所 2021-09-07 — — CN disclosed
WO-2021063915-A1 ANTIBACTERIAL COMPOUNDS Janssen Sciences Ireland Unlimited Company (IE) 2021-04-08 — — WO disclosed
CN-112174869-A Preparation method and medicinal application of N-phenylacetyl-2-hydroxymethyl pyrrolidine-2-formamide 蔡霈 2021-01-05 — — CN disclosed
CN-110036014-A A kind of compound and its preparation and application with AXL inhibitory activity 中国科学院上海药物研究所 2019-07-19 — — CN disclosed
CN-108250200-A A kind of compound and its preparation and application with Axl inhibitory activity 中国科学院上海药物研究所 2018-07-06 — — CN disclosed
WO-2007124136-A1 USE OF 4-AMINO-PIPERIDINES FOR TREATING SLEEP DISORDERS ACADIA PHARMACEUTICALS, INC. (US) 2007-11-01 — — WO disclosed
EP-1817282-A1 PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES AstraZeneca AB (SE) 2007-08-15 — — EP disclosed
US-7253186-B2 N-substituted piperidine derivatives as serotonin receptor agents ACADIA PHARMACEUTICALS, INC. 2007-08-07 — — US disclosed
US-20060205722-A1 N-substituted piperidine derivatives as serotonin receptor agents ACADIA PHARMACEUTICALS, INC. 2006-09-14 — — US disclosed
US-20060199818-A1 N-substituted piperidine derivatives as serotonin receptor agents ACADIA PHARMACEUTICALS INC. 2006-09-07 — — US disclosed
WO-2006056752-A1 PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES ASTRAZENECA AB (SE) 2006-06-01 — — WO disclosed
US-20060094758-A1 N-substituted piperidine derivatives as serotonin receptor agents ACADIA PHARMACEUTICALS, INC. 2006-05-04 — — US disclosed
EP-1562937-A2 N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS Acadia Pharmaceuticals Inc. (US) 2005-08-17 — — EP disclosed
US-20040106600-A1 N-substituted piperidine derivatives as serotonin receptor agents ACADIA PHARMACEUTICALS, INC. 2004-06-03 — — US disclosed
WO-2004000808-A2 N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS ACADIA PHARMACEUTICALS INC. (US) 2003-12-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040106600-A1 N-substituted piperidine derivatives as serotonin receptor agents HTR1A, HTR5A, HTR1B NLRP3 3199/4885EPHX2 2012/4885LTA4H 2469/4885
US-20220372033-A1 ANTIBACTERIAL COMPOUNDS NDUFS3, SQOR, MT-ND4 NLRP3 979/4885EPHX2 3787/4885LTA4H 826/4885
US-20060094758-A1 N-substituted piperidine derivatives as serotonin receptor agents HTR1A, HTR5A, HTR1B NLRP3 3284/4885EPHX2 1967/4885LTA4H 2522/4885
US-20060205722-A1 N-substituted piperidine derivatives as serotonin receptor agents HTR1A, HTR5A, HTR1B NLRP3 3284/4885EPHX2 1967/4885LTA4H 2522/4885
US-20060199818-A1 N-substituted piperidine derivatives as serotonin receptor agents HTR1A, HTR5A, HTR1B NLRP3 3284/4885EPHX2 1967/4885LTA4H 2522/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.