SCHEMBL378766

SCHEMBL378766

O=C(O)Cc1ccc(OC(F)(F)F)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 3/20 0.54
LTA4H P09960 1/20 0.54
NLRP3 Q96P20 1/20 0.51
CA2 P00918 1/20 0.50
CAMK2A Q9UQM7 1/20 0.50
HRH3 Q9Y5N1 2/20 0.49
MAPK8 P45983 1/20 0.49
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
RXRA P19793 2/20 0.49
RXRB P28702 2/20 0.49
RXRG P48443 2/20 0.49
SRD5A2 P31213 1/20 0.49
AKR1B1 P15121 1/20 0.48
EPHX1 P07099 1/20 0.48
MRGPRX4 Q96LA9 1/20 0.48
CACNA1G O43497 1/20 0.47
CACNA1H O95180 1/20 0.47
CACNA1I Q9P0X4 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1373117 0.98 EPHX2 (0.52) EPHX2LTA4HNLRP3CA2CAMK2A
SCHEMBL27028196 0.95 EPHX2 (0.60) EPHX2LTA4HNLRP3CA2CAMK2A
SCHEMBL19611683 0.86 EPHX2 (0.56) EPHX2LTA4HNLRP3CA2CAMK2A
SCHEMBL31264426 0.85 EPHX2 (0.51) EPHX2LTA4HNLRP3HRH3MAPK8
SCHEMBL1462002 0.83 NLRP3 (0.50) EPHX2LTA4HNLRP3HRH3MAPK8
SCHEMBL328546 0.83 MAPK8 (0.55) EPHX2LTA4HNLRP3CA2MAPK8
SCHEMBL7983265 0.83 POLB (0.56) EPHX2LTA4HNLRP3HRH3MAPK8
SCHEMBL11463213 0.82 RXRA (0.47) CA2CAMK2AHRH3SMN1; SMN2RXRA
SCHEMBL584599 0.81 FFAR1 (0.64) SRD5A2LMNA
SCHEMBL22816202 0.81 VNN1 (0.49) EPHX2LTA4HNLRP3HRH3MAPK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 497 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118322684-B Dampproof antibacterial car foot pad and preparation method thereof 广东安拓普聚合物科技股份有限公司 2024-09-24 CN claimed
CN-118322684-A Dampproof antibacterial car foot pad and preparation method thereof 广东安拓普聚合物科技股份有限公司 2024-07-12 CN claimed
CN-102977098-B Aryl-substituted indolizine derivative and preparation method and applications thereof UNIV SHAOXING 2015-04-01 CN claimed
CN-102977098-A Aryl-substituted indolizine derivative and preparation method and applications thereof UNIV SHAOXING 2013-03-20 CN claimed
EP-3704094-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-11 EP disclosed
US-20250388536-A1 3-ALKYNYL CARBOXAMIDES AS AEP MODULATORS HOFFMANN-LA ROCHE INC. (US) 2025-12-25 US disclosed
US-20250361250-A1 FLUORINE-CONTAINING SILANE COMPOUND DAIKIN INDUSTRIES, LTD. (JP) 2025-11-27 US disclosed
US-20250333902-A1 FLUORINE-CONTAINING COMPOUND DAIKIN INDUSTRIES, LTD. (JP) 2025-10-30 US disclosed
EP-4625046-A2 COMPOSITION FOR FORMING ORGANIC FILM, METHOD FOR FORMING ORGANIC FILM, PATTERNING PROCESS, MONOMER, AND POLYMER Shin-Etsu Chemical Co., Ltd. (JP) 2025-10-01 EP disclosed
US-20250297127-A1 COMPOSITION FOR FORMING ORGANIC FILM, METHOD FOR FORMING ORGANIC FILM, PATTERNING PROCESS, MONOMER, AND POLYMER SHIN-ETSU CHEMICAL CO., LTD. (JP) 2025-09-25 US disclosed
US-20250122188-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2025-04-17 US disclosed
WO-2025064683-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2025-03-27 WO disclosed
EP-0888317-A1 SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA GLAXO GROUP LIMITED (GB) 1999-01-07 EP disclosed
EP-0866793-A4 1998-10-07 EP disclosed
EP-0866793-A1 NITROIMIDAZOLE ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF PATHOGENESIS CORPORATION (US) 1998-09-30 EP disclosed
WO-1997031907-A1 SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA GLAXO GROUP LIMITED (GB) 1997-09-04 WO disclosed
WO-1997001562-A1 NITROIMIDAZOLE ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF PATHOGENESIS CORPORATION (US) 1997-01-16 WO disclosed
US-5387585-A Treating epilepsy, anxiety, sleep disorders, schizophrnia, senile dementia HOFFMANN-LA ROCHE INC. (US) 1995-02-07 US disclosed
EP-0519307-A2 Tetracyclic Imidazodiazepines F. HOFFMANN-LA ROCHE AG (CH) 1992-12-23 EP disclosed
US-4199595-A M-phenoxybenzyl and α-cyano-M-phenoxybenzyl esters of 2-haloalkyl (oxy-, thio-, sulfinyl-, or sulfonyl)phenylalkanoic acids AMERICAN CYANAMID COMPANY (US) 1980-04-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250122188-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 EPHX2 3932/4885LTA4H 3603/4885NLRP3 1387/4885
US-20250297127-A1 COMPOSITION FOR FORMING ORGANIC FILM, METHOD FOR FORMING ORGANIC FILM, PATTERNING PROCESS, MONOMER, AND POLYMER SLIRP, RER1, ECPAS EPHX2 97/4885LTA4H 2572/4885NLRP3 1294/4885
US-20250388536-A1 3-ALKYNYL CARBOXAMIDES AS AEP MODULATORS CNR2, CNR1, FAAH2 EPHX2 57/4885LTA4H 1842/4885NLRP3 4865/4885
US-20250361250-A1 FLUORINE-CONTAINING SILANE COMPOUND FLI1, AFF1, RFT1 EPHX2 3616/4885LTA4H 3895/4885NLRP3 2371/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.