SCHEMBL146549

SCHEMBL146549

C=C(C)C(=O)Oc1ccsc1CC

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.38
ELANE P08246 1/20 0.38
KEAP1 Q14145 1/20 0.37
ATM Q13315 2/20 0.36
ALDH1A1 P00352 3/20 0.33
CYP1A2 P05177 2/20 0.33
MEN1 O00255 1/20 0.33
THRB P10828 1/20 0.33
TSHR P16473 3/20 0.33
ALOX5 P09917 1/20 0.32
RIPK1 Q13546 1/20 0.31
POLB P06746 1/20 0.31
APEX1 P27695 1/20 0.31
HTT P42858 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
KDM4E B2RXH2 3/20 0.31
HPGD P15428 1/20 0.31
HSD17B10 Q99714 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
CYP3A4 P08684 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27830743 0.86 TSHR (0.38) KMT2AELANEKEAP1ALDH1A1CYP1A2
SCHEMBL146229 0.78 THRB (0.45) KMT2AKEAP1ATMALDH1A1CYP1A2
SCHEMBL28339384 0.78 KMT2A (0.48) KMT2AELANEALDH1A1CYP1A2MEN1
SCHEMBL7079234 0.77 KMT2A (0.40) KMT2AELANEKEAP1ATMALDH1A1
SCHEMBL29225292 0.76 ELANE (0.38) KMT2AELANEATMALDH1A1CYP1A2
SCHEMBL15309678 0.74 ELANE (0.42) KMT2AELANEATMALDH1A1THRB
SCHEMBL3946663 0.72 L3MBTL1 (0.50) KMT2AALDH1A1CYP1A2MEN1TSHR
SCHEMBL27849214 0.72 ELANE (0.45) KMT2AELANEATMALDH1A1MEN1
SCHEMBL10737748 0.72 KDM4E (0.38) KMT2AKEAP1ALDH1A1CYP1A2MEN1
SCHEMBL147468 0.71 ELANE (0.47) ELANEATMALDH1A1THRBTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 294 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023218463-A1 RADIATION INDUCED RADICAL CURING BY SEMICONDUCTING NANOPARTICLES YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2023-11-16 WO claimed
EP-2303331-B1 OPHTHALMIC DEVICE HAVING THERAPEUTIC AGENT DELIVERY CAPABILITY AND METHOD OF FORMING SAME ALCON INC (CH) 2022-01-26 EP claimed
US-20180346629-A1 Biocompatible polymers and co-polymers, and uses thereof GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE 2018-12-06 US claimed
EP-2292672-B1 Biocompatible polymers and co-polymers comprising amino acids in the side chain CIS PHARMA AG (CH) 2018-05-09 EP claimed
US-20170152335-A1 Biocompatible polymers and co-polymers, and uses thereof HITZ HANS (CH) 2017-06-01 US claimed
EP-1888660-B1 BIOCOMPATIBLE POLYMERS AND CO-POLYMERS COMPRISING AMINO ACIDS IN THE SIDE CHAIN CIS PHARMA AG (CH) 2017-05-17 EP claimed
CN-104903419-B Adhesive composition 东友精细化工有限公司 2016-12-21 CN claimed
CN-104903419-A Adhesive composition DONGWOO FINE CHEM CO LTD 2015-09-09 CN claimed
US-8980957-B2 Methods for the preparation of biocompatible polymers, the polymers and their uses CIS PHARMA AG (CH) 2015-03-17 US claimed
US-8901218-B2 Branched (meth)acrylate copolymer with high refractive index and method for preparing the same CHEIL INDUSTRIES INC. (KR) 2014-12-02 US claimed
WO-2005026787-A1 PROCESS FOR MANUFACTURING INTRAOCULAR LENSES WITH BLUE LIGHT ABSORPTION CHARACTERISTICS BAUSCH & LOMB INCORPORATED (US) 2005-03-24 WO claimed
US-20050055090-A1 Process for manufacturing intraocular lenses with blue light absorption characteristics BAUSCH HEALTH US, LLC 2005-03-10 US claimed
EP-0914169-B1 MATERIALS FOR USE IN GLAUCOMA FILTRATION DEVICES ALCON LAB INC (US) 2003-07-30 EP claimed
EP-0914169-A3 MATERIALS FOR USE IN GLAUCOMA FILTRATION DEVICES ALCON LABORATORIES, INC. (US) 2002-08-28 EP claimed
US-6353069-B1 INTRAOCULAR LENSES THAT HAVE HIGH REFRACTIVE INDEXES, ARE FLEXIBLE AND TRANSPARENT, CAN BE INSERTED INTO EYE THROUGH RELATIVELY SMALL INCISION, RECOVER ORIGINAL SHAPE AFTER HAVING BEEN INSERTED, AND ARE FREE OF GLISTENINGS ALCON MANUFACTURING, LTD. 2002-03-05 US claimed
EP-1080382-A1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS Alcon Laboratories, Inc. (US) 2001-03-07 EP claimed
US-6001128-A CROSSLINKED ACRYLATED ESTER ALCON LABORATORIES, INC. (US) 1999-12-14 US claimed
WO-1999053347-A1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS ALCON LABORATORIES, INC. (US) 1999-10-21 WO claimed
EP-0914169-A2 MATERIALS FOR USE IN GLAUCOMA FILTRATION DEVICES ALCON LABORATORIES, INC. (US) 1999-05-12 EP claimed
WO-1998053862-A2 MATERIALS FOR USE IN GLAUCOMA FILTRATION DEVICES ALCON LABORATORIES, INC. (US) 1998-12-03 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170152335-A1 Biocompatible polymers and co-polymers, and uses thereof ARG1, CRYAA, COL1A1 KMT2A 3308/4885ELANE 1009/4885KEAP1 1248/4885
US-20180346629-A1 Biocompatible polymers and co-polymers, and uses thereof ARG1, CRYAA, COL1A1 KMT2A 3308/4885ELANE 1009/4885KEAP1 1248/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.