Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.64 |
| ▸ | EBP | Q15125 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.64 |
| ▸ | DRD3 | P35462 | 2/20 | 0.64 |
| ▸ | HTR6 | P50406 | 2/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | IDH1 | O75874 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964377 | 1.00 | ESR1 (0.64) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL18722849 | 0.95 | ESR1 (0.58) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL8614808 | 0.92 | ESR1 (0.61) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL8614813 | 0.92 | ESR1 (0.61) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL8614816 | 0.92 | ESR1 (0.61) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL15788566 | 0.84 | ESR1 (0.59) | ESR1ESR2CYP19A1 | |
| SCHEMBL17790415 | 0.84 | ESR1 (0.72) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL17790416 | 0.84 | ESR1 (0.72) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL8613912 | 0.83 | ESR1 (0.60) | ESR1EBPKMT2AKCNH2SIGMAR1 | |
| SCHEMBL8613917 | 0.83 | ESR1 (0.60) | ESR1EBPKMT2AKCNH2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981906-B2 | Trans-clomiphene metabolites and uses thereof | REPROS THERAPEUTICS INC. (US) | 2018-05-29 | — | — | US | disclosed |
| US-9981906-B2 | Trans-clomiphene metabolites and uses thereof | REPROS THERAPEUTICS INC. (US) | 2018-05-29 | — | — | US | disclosed |
| EP-3083552-B1 | STABLE SOLID FORMS OF ENCLOMIPHENE AND ENCLOMIPHENE CITRATE | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2018-03-14 | — | — | EP | disclosed |
| US-20170349533-A1 | STABLE SOLID FORMS OF ENCLOMIPHENE AND ENCLOMIPHENE CITRATE | F I S - FABBRICA ITALIANA SINTETICI S P A (IT) | 2017-12-07 | — | — | US | disclosed |
| US-20170349533-A1 | STABLE SOLID FORMS OF ENCLOMIPHENE AND ENCLOMIPHENE CITRATE | F I S - FABBRICA ITALIANA SINTETICI S P A (IT) | 2017-12-07 | — | — | US | disclosed |
| US-9822063-B2 | Stable solid forms of enclomiphene and enclomiphene citrate | F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A (IT) | 2017-11-21 | — | — | US | disclosed |
| US-9822063-B2 | Stable solid forms of enclomiphene and enclomiphene citrate | F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A (IT) | 2017-11-21 | — | — | US | disclosed |
| US-20160347705-A1 | STABLE SOLID FORMS OF ENCLOMIPHENE AND ENCLOMIPHENE CITRATE | F.I.S.- FABBRICA ITALIANA SINTETICI S.P.A (IT) | 2016-12-01 | — | — | US | disclosed |
| US-20160347705-A1 | STABLE SOLID FORMS OF ENCLOMIPHENE AND ENCLOMIPHENE CITRATE | F.I.S.- FABBRICA ITALIANA SINTETICI S.P.A (IT) | 2016-12-01 | — | — | US | disclosed |
| EP-3015453-B1 | Process for the preparation of Clomiphene | ITALIANA SINT SPA (IT) | 2016-10-12 | — | — | EP | disclosed |
| US-9428442-B2 | Process for the preparation of Clomiphene | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2016-08-30 | — | — | US | disclosed |
| US-9428442-B2 | Process for the preparation of Clomiphene | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2016-08-30 | — | — | US | disclosed |
| US-20160152551-A1 | PROCESS FOR THE PREPARATION OF CLOMIPHENE | F.I.S.- FABBRICA ITALIANA SINTETICI S.P.A (IT) | 2016-06-02 | — | — | US | disclosed |
| US-20160152551-A1 | PROCESS FOR THE PREPARATION OF CLOMIPHENE | F.I.S.- FABBRICA ITALIANA SINTETICI S.P.A (IT) | 2016-06-02 | — | — | US | disclosed |
| WO-2016066584-A1 | STABLE SOLID FORMS OF ENCLOMIPHENE AND ENCLOMIPHENE CITRATE | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2016-05-06 | — | — | WO | disclosed |
| EP-3015453-A1 | Process for the preparation of Clomiphene | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2016-05-04 | — | — | EP | disclosed |
| EP-3015454-A1 | Stable solid form of trans-Clomiphene citrate | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2016-05-04 | — | — | EP | disclosed |
| US-20140163114-A1 | TRANS-CLOMIPHENE METABOLITES AND USES THEREOF | REPROS THERAPEUTICS INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140163114-A1 | TRANS-CLOMIPHENE METABOLITES AND USES THEREOF | REPROS THERAPEUTICS INC. (US) | 2014-06-12 | — | — | US | disclosed |
| WO-2013020017-A1 | TRANS-CLOMIPHENE METABOLITES AND USES THEREOF | REPROS THERAPEUTICS INC. (US) | 2013-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163114-A1 | TRANS-CLOMIPHENE METABOLITES AND USES THEREOF | SHBG, CYP19A1, HMGCR | ESR1 111/4885EBP 423/4885KMT2A 665/4885 |
| US-20160152551-A1 | PROCESS FOR THE PREPARATION OF CLOMIPHENE | CYP19A1, CYP11A1, SI | ESR1 918/4885EBP 2258/4885KMT2A 2471/4885 |
| US-20160347705-A1 | STABLE SOLID FORMS OF ENCLOMIPHENE AND ENCLOMIPHENE CITRATE | CS, ACLY, OAT | ESR1 895/4885EBP 3148/4885KMT2A 3745/4885 |
| US-20170349533-A1 | STABLE SOLID FORMS OF ENCLOMIPHENE AND ENCLOMIPHENE CITRATE | CS, ACLY, OAT | ESR1 895/4885EBP 3148/4885KMT2A 3745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.