SCHEMBL14698292

SCHEMBL14698292

O=C(Cl)c1cc(C(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LIMK1 P53667 2/20 0.39
LIMK2 P53671 2/20 0.39
SMARCA2 P51531 1/20 0.35
MALT1 Q9UDY8 4/20 0.35
TRPV1 Q8NER1 5/20 0.35
TRPA1 O75762 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30070407 0.90 ALDH1A1 (0.44) LIMK1LIMK2SMARCA2MALT1TRPV1
SCHEMBL4072179 0.90 ALDH1A1 (0.44) LIMK1LIMK2SMARCA2MALT1TRPV1
SCHEMBL15775839 0.89 SCN9A (0.39) LIMK1LIMK2SMARCA2MALT1TRPV1
SCHEMBL14698494 0.84 HSD11B1 (0.40) TRPV1TRPA1
SCHEMBL25275622 0.83 ALDH1A1 (0.44) LIMK1LIMK2
SCHEMBL30466605 0.83 ALDH1A1 (0.44) LIMK1LIMK2
SCHEMBL14234689 0.82 TRPA1 (0.38) MALT1TRPV1TRPA1
SCHEMBL29558552 0.82 TRPA1 (0.38) MALT1TRPV1TRPA1
SCHEMBL28812160 0.81 TRPA1 (0.37) MALT1TRPV1TRPA1
SCHEMBL590879 0.80 DHODH (0.41) MALT1TRPV1TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9556141-B2 Process for preparing N-substituted 1H-pyrazole-5-carboxylate compounds and derivatives thereof BASF SE (DE) 2017-01-31 US disclosed
EP-2782910-B1 PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBOXYLATE COMPOUNDS AND DERIVATIVES THEREOF BASF SE (DE) 2016-02-03 EP disclosed
US-20150087843-A1 Process for preparing N-substituted 1H-pyrazole-5-carboxylate compounds and derivatives thereof BASF SE (DE) 2015-03-26 US disclosed
US-8921567-B2 Process for preparing N-substituted 1H-pyrazole-5-carbonylchloride compounds BASF SE (DE) 2014-12-30 US disclosed
EP-2782910-A1 PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBOXYLATE COMPOUNDS AND DERIVATIVES THEREOF BASF SE (DE) 2014-10-01 EP disclosed
WO-2014128136-A1 ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2014-08-28 WO disclosed
US-20140179519-A1 N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2014-06-26 US disclosed
EP-2742036-A1 N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2014-06-18 EP disclosed
EP-2742035-A1 PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBONYLCHLORIDE COMPOUNDS BASF SE (DE) 2014-06-18 EP disclosed
US-20140163234-A1 Process for preparing N-substituted 1H-pyrazole-5-carbonylchloride compounds BASF SE (DE) 2014-06-12 US disclosed
CN-103827103-A N-thio-anthranilamide compounds and their use as pesticides BASF SE 2014-05-28 CN disclosed
WO-2013076092-A1 PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBOXYLATE COMPOUNDS AND DERIVATIVES THEREOF BASF SE (DE) 2013-05-30 WO disclosed
WO-2013024010-A1 N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2013-02-21 WO disclosed
WO-2013024007-A1 PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBONYLCHLORIDE COMPOUNDS BASF SE (DE) 2013-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140179519-A1 N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES NAT1, ANTXR2, ATL3 LIMK1 4327/4885LIMK2 4106/4885SMARCA2 4482/4885
US-20150087843-A1 Process for preparing N-substituted 1H-pyrazole-5-carboxylate compounds and derivatives thereof CA5B, CA5A, PC LIMK1 2238/4885LIMK2 2709/4885SMARCA2 2982/4885
US-20140163234-A1 Process for preparing N-substituted 1H-pyrazole-5-carbonylchloride compounds CDK13, C5, C9 LIMK1 2227/4885LIMK2 1898/4885SMARCA2 4243/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.