SCHEMBL14701275

SCHEMBL14701275

C=CC(=O)OCc1c2ccccc2c(NS(=O)(=O)C(F)(F)F)c2ccccc12

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.35
MAPK1 P28482 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CA2 P00918 1/20 0.33
PTPN1 P18031 1/20 0.32
SLC22A12 Q96S37 1/20 0.32
EPHX1 P07099 1/20 0.32
PTGS1 P23219 4/20 0.31
PTGS2 P35354 4/20 0.31
CYSLTR2 Q9NS75 1/20 0.30
CYSLTR1 Q9Y271 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14701276 0.79 CA2 (0.36) THRBCA2SLC22A12PTGS1PTGS2
SCHEMBL14701272 0.75 THRB (0.37) THRBMAPK1
SCHEMBL14701283 0.75 THRB (0.41) THRBMAPK1SMN1; SMN2CA2EPHX1
SCHEMBL14701259 0.74 THRB (0.45) THRBMAPK1SMN1; SMN2EPHX1
SCHEMBL16271386 0.73 THRB (0.44) THRBSMN1; SMN2
SCHEMBL14701266 0.72 THRB (0.46) THRBMAPK1SMN1; SMN2EPHX1
SCHEMBL14701257 0.71 THRB (0.40) THRBMAPK1SMN1; SMN2EPHX1
SCHEMBL68439 0.70 EPHX1 (0.50) THRBMAPK1SMN1; SMN2EPHX1
SCHEMBL29531071 0.70 EPHX1 (0.50) THRBMAPK1SMN1; SMN2EPHX1
SCHEMBL14701243 0.68 MAPK1 (0.35) MAPK1SMN1; SMN2CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9040225-B2 Developable bottom antireflective coating composition and pattern forming method using thereof INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2015-05-26 US disclosed
US-8999624-B2 Developable bottom antireflective coating composition and pattern forming method using thereof INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2015-04-07 US disclosed
US-20150050601-A1 DEVELOPABLE BOTTOM ANTIREFLECTIVE COATING COMPOSITION AND PATTERN FORMING METHOD USING THEREOF GLOBALFOUNDRIES U.S. INC. 2015-02-19 US disclosed
US-8715907-B2 Developable bottom antireflective coating compositions for negative resists INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2014-05-06 US disclosed
US-20130040238-A1 DEVELOPABLE BOTTOM ANTIREFLECTIVE COATING COMPOSITIONS FOR NEGATIVE RESISTS INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2013-02-14 US disclosed