SCHEMBL1471226

SCHEMBL1471226

c1ccc2c(c1)CNC2c1ncc[nH]1

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ADRA1A P35348 15/20 0.56
ADRA2A P08913 5/20 0.54
ADRA1D P25100 4/20 0.54
ADRA1B P35368 2/20 0.54
NISCH Q9Y2I1 1/20 0.41
RECQL P46063 1/20 0.41
HTR2B P41595 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6659680 0.72 TRPM5 (0.41) ADRA2ARECQL
SCHEMBL966691 0.72 ADRA1A (1.00) ADRA1AADRA2AADRA1DADRA1B
SCHEMBL31484206 0.72 ADRA1A (1.00) ADRA1AADRA2AADRA1DADRA1B
SCHEMBL687569 0.72 TAAR1 (0.41) ADRA1AADRA2AADRA1DADRA1BHTR2B
SCHEMBL537787 0.70 DRD1 (0.38) ADRA2A
SCHEMBL9531751 0.70 ADRA1A (0.55) ADRA1AADRA2AADRA1DADRA1BNISCH
SCHEMBL769101 0.70 ADRA1A (1.00) ADRA1AADRA2AADRA1DADRA1B
SCHEMBL10387446 0.69 ADRA1A (0.58) ADRA1AADRA2AADRA1DADRA1BNISCH
SCHEMBL6985456 0.69 PRCP (0.66) RECQL
SCHEMBL11244413 0.68 ADRA1A (0.50) ADRA1AADRA2AADRA1DADRA1BNISCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0072954-B1 ISOINDOLIN-2-YL-AMINO-IMIDAZOLINES AND ISOINDOLIN-2-YL GUANIDINES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINES Beiersdorf Aktiengesellschaft (DE) 1986-12-30 EP claimed
EP-0072954-A2 Isoindolin-2-yl-amino-imidazolines and isoindolin-2-yl guanidines, process for their preparation and their use as medicines Beiersdorf Aktiengesellschaft (DE) 1983-03-02 EP claimed
US-9044413-B2 Block polymers, compositions and methods for use for foams, laundry detergents, and shower rinses and coagulants SOLVAY USA INC. (US) 2015-06-02 US disclosed
US-8907033-B2 Polymers, compositions and methods of use for foams, laundry detergents, shower rinses and coagulants SOLVAY USA INC. (US) 2014-12-09 US disclosed
EP-1322684-B1 PROCESSES TO CONTROL THE RESIDUAL MONOMER LEVEL OF COPOLYMERS OF TERTIARY AMINO MONOMER WITH A VINYL-FUNCTIONAL MONOMER SOLVAY USA INC (US) 2014-05-07 EP disclosed
US-20140034076-A1 POLYMERS, COMPOSITIONS AND METHODS OF USE FOR FOAMS, LAUNDRY DETERGENTS, SHOWER RINSES AND COAGULANTS RHODIA INC. (US) 2014-02-06 US disclosed
US-8580905-B2 Polymers, compositions and methods of use for foams, laundry detergents, shower rinses and coagulants RHODIA INC. (US) 2013-11-12 US disclosed
US-20130295032-A1 BLOCK POLYMERS, COMPOSITIONS AND METHODS FOR USE FOR FOAMS, LAUNDRY DETERGENTS, AND SHOWER RINSES AND COAGULANTS RHODIA (US) 2013-11-07 US disclosed
US-20130237471-A1 POLYMERS, COMPOSITIONS AND METHODS OF USE FOR FOAMS, LAUNDRY DETERGENTS, SHOWER RINSES AND COAGULANTS RHODIA INC. (US) 2013-09-12 US disclosed
US-8492481-B2 Block polymers, compositions and methods for use for foams, laundry detergents, and shower rinses and coagulants RHODIA INC. (US) 2013-07-23 US disclosed
US-8445616-B2 Polymers, compositions and methods of use for foams, laundry detergents, shower rinses and coagulants RHODIA INC. (US) 2013-05-21 US disclosed
WO-2000071652-A2 DETERGENT COMPOSITIONS COMPRISING POLYMERIC SUDS VOLUME AND SUDS DURATION ENHANCERS THE PROCTER & GAMBLE COMPANY (US) 2000-11-30 WO disclosed
WO-2000071241-A1 COMPOSITIONS AND METHODS FOR USING POLYMERIC SUDS ENHANCERS THE PROCTER & GAMBLE COMPANY (US) 2000-11-30 WO disclosed
EP-1032634-A1 DETERGENT COMPOSITIONS COMPRISING POLYMERIC SUDS ENHANCERS AND THEIR USE THE PROCTER & GAMBLE COMPANY (US) 2000-09-06 EP disclosed
EP-1032633-A1 LIQUID DETERGENT COMPOSITIONS COMPRISING POLYMERIC SUDS ENHANCERS THE PROCTER & GAMBLE COMPANY (US) 2000-09-06 EP disclosed
WO-2000029535-A1 CLEANING PRODUCT WHICH USES SONIC OR ULTRASONIC WAVES THE PROCTER & GAMBLE COMPANY (US) 2000-05-25 WO disclosed
WO-2000029540-A1 ULTRASONIC CLEANING COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2000-05-25 WO disclosed
WO-2000028874-A2 ULTRASONIC CLEANING DEVICE THE PROCTER & GAMBLE COMPANY (US) 2000-05-25 WO disclosed
WO-1999027058-A1 DETERGENT COMPOSITIONS COMPRISING POLYMERIC SUDS ENHANCERS AND THEIR USE THE PROCTER & GAMBLE COMPANY (US) 1999-06-03 WO disclosed
WO-1999027057-A1 LIQUID DETERGENT COMPOSITIONS COMPRISING POLYMERIC SUDS ENHANCERS THE PROCTER & GAMBLE COMPANY (US) 1999-06-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130295032-A1 BLOCK POLYMERS, COMPOSITIONS AND METHODS FOR USE FOR FOAMS, LAUNDRY DETERGENTS, AND SHOWER RINSES AND COAGULANTS CUTA, DAGLB, GZMB ADRA1A 4200/4885ADRA2A 3516/4885ADRA1D 4118/4885
US-20140034076-A1 POLYMERS, COMPOSITIONS AND METHODS OF USE FOR FOAMS, LAUNDRY DETERGENTS, SHOWER RINSES AND COAGULANTS DSG1, DSTN, CUTA ADRA1A 4484/4885ADRA2A 4372/4885ADRA1D 4493/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.