Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720137 | 0.82 | KMT2A (0.54) | NPC1RAB9APOLBTP53 | |
| SCHEMBL14720296 | 0.78 | MAP2K1 (0.43) | NPC1RAB9AALDH1A1MAPTGAA | |
| SCHEMBL14720555 | 0.76 | FASN (0.37) | — | |
| SCHEMBL14720417 | 0.70 | HDAC3 (0.41) | NPC1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL14720397 | 0.70 | THRB (0.58) | AAK1NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL14720195 | 0.70 | USP30 (0.55) | AAK1NPC1ALDH1A1MAPTTDP1 | |
| SCHEMBL2491853 | 0.68 | LMNA (0.66) | NPC1RAB9AALDH1A1MAPTTDP1 | |
| SCHEMBL14720616 | 0.68 | LIMK2 (0.36) | — | |
| SCHEMBL1762219 | 0.67 | NPC1 (0.59) | NPC1RAB9AALDH1A1MAPTTDP1 | |
| SCHEMBL6004945 | 0.66 | SMN1; SMN2 (0.63) | NPC1RAB9AALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028445-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |