Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14722538 | 0.80 | POLB (0.36) | HRH3SRD5A2 | |
| SCHEMBL14722411 | 0.80 | SRD5A1 (0.44) | SRD5A2ALDH1A1TSHR | |
| SCHEMBL14721179 | 0.76 | L3MBTL1 (0.50) | HRH3SRD5A2 | |
| SCHEMBL14720463 | 0.76 | L3MBTL1 (0.47) | HRH3SRD5A2KMT2AALDH1A1 | |
| SCHEMBL14720575 | 0.75 | L3MBTL3 (0.51) | HRH3MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL14720649 | 0.73 | FKBP1A (0.35) | HRH3SRD5A2MEN1KMT2AALDH1A1 | |
| SCHEMBL14722442 | 0.73 | GRM2 (0.47) | HRH3SRD5A2MEN1KMT2A | |
| SCHEMBL14721067 | 0.73 | SRD5A2 (0.42) | HRH3SRD5A2ALDH1A1KDM4E | |
| SCHEMBL14721926 | 0.73 | POLB (0.39) | SRD5A2ALDH1A1KDM4E | |
| SCHEMBL14720710 | 0.72 | HRH3 (0.56) | HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |