Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14725387 | 0.87 | EPHX2 (0.38) | EPHX2KMT2ACHRM3FABP5 | |
| SCHEMBL14725519 | 0.80 | TUBB4A (0.37) | — | |
| SCHEMBL14725502 | 0.80 | TUBB4A (0.37) | LMNAHTT | |
| SCHEMBL14725525 | 0.78 | BTK (0.37) | BACE1 | |
| SCHEMBL14725529 | 0.72 | MMP1 (0.35) | KMT2ASMN1; SMN2BACE1 | |
| SCHEMBL7927995 | 0.69 | LTB4R (0.52) | EPHX2KMT2ALMNAFABP5 | |
| SCHEMBL14722316 | 0.69 | MEN1 (0.35) | KMT2ALMNATSHRNPSR1 | |
| SCHEMBL14722069 | 0.69 | TUBB1 (0.39) | KMT2ALMNACYP2C9 | |
| SCHEMBL18103625 | 0.68 | EPHX2 (0.50) | EPHX2KMT2AUSP2LMNATP53 | |
| SCHEMBL31173117 | 0.68 | EPHX2 (0.52) | EPHX2KMT2ACHRM3USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026942-A1 | TUBULIN BINDING AGENTS | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2013-02-28 | — | — | WO | disclosed |