Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 9/20 | 0.52 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | PKLR | P30613 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28227505 | 0.96 | PTGS2 (0.52) | PTGS2CA12CA2CA9CA1 | |
| SCHEMBL310987 | 0.96 | PTGS2 (0.52) | PTGS2CA12CA2CA9CA1 | |
| SCHEMBL31323345 | 0.96 | PTGS2 (0.52) | PTGS2CA12CA2CA9CA1 | |
| Water SCHEMBL31291030 | 0.94 | PTGS2 (0.50) | PTGS2CA12CA2CA9CA1 | |
| Water SCHEMBL15672825 | 0.94 | PTGS2 (0.50) | PTGS2CA12CA2CA9CA1 | |
| Potassium Ion SCHEMBL3400358 | 0.94 | PTGS2 (0.48) | PTGS2CA12CA2CA9CA1 | |
| SCHEMBL1870051 | 0.89 | PTGS2 (0.48) | PTGS2CA12CA2CA9CA1 | |
| Lithium Ion SCHEMBL3173871 | 0.89 | PTGS2 (0.48) | PTGS2CA12CA2CA9CA1 | |
| SCHEMBL29194064 | 0.89 | PTGS2 (0.48) | PTGS2CA12CA2CA9CA1 | |
| SCHEMBL31276980 | 0.89 | PTGS2 (0.48) | PTGS2CA12CA2CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130059151-A1 | MAGNESIUM OXIDE FOR PHARMACEUTICAL PREPARATION | TOMITA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-07 | — | — | US | disclosed |