Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14744260 | 0.94 | SMN1; SMN2 (0.55) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL14742969 | 0.89 | MEN1 (0.50) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL14743294 | 0.87 | POLB (0.55) | POLBSMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL14743367 | 0.82 | GAA (0.55) | POLBSMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL14743721 | 0.81 | ALDH1A1 (0.54) | POLBHPGDALDH1A1HTTMEN1 | |
| SCHEMBL14742913 | 0.80 | RAB9A (0.49) | HPGDRAB9AALDH1A1CYP1A2MEN1 | |
| SCHEMBL14743714 | 0.78 | MAPT (0.56) | POLBSMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL14743078 | 0.78 | HTT (0.50) | POLBHPGDNPC1ALDH1A1HTT | |
| SCHEMBL14744244 | 0.78 | MAPK8 (0.49) | POLBNPC1RAB9AALDH1A1HTT | |
| SCHEMBL14743578 | 0.78 | RORC (0.44) | POLBALDH1A1CYP1A2CYP2C9HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013030358-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-03-07 | — | — | WO | disclosed |