Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14744254 | 0.94 | POLB (0.49) | SMN1; SMN2HPGDKDM4EALDH1A1ALOX15 | |
| SCHEMBL14743294 | 0.89 | POLB (0.55) | SMN1; SMN2HPGDALDH1A1MAPK1RAB9A | |
| SCHEMBL14743367 | 0.89 | GAA (0.55) | SMN1; SMN2HPGDALDH1A1ALOX15MAPK1 | |
| SCHEMBL14743721 | 0.83 | ALDH1A1 (0.54) | HPGDKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14742969 | 0.82 | MEN1 (0.50) | SMN1; SMN2ALDH1A1ALOX15MAPK1RAB9A | |
| SCHEMBL14742913 | 0.82 | RAB9A (0.49) | HPGDKDM4EALDH1A1MAPK1RAB9A | |
| SCHEMBL14743714 | 0.80 | MAPT (0.56) | SMN1; SMN2HPGDKDM4EALDH1A1RAB9A | |
| SCHEMBL14743078 | 0.80 | HTT (0.50) | HPGDKDM4EALDH1A1NPC1MEN1 | |
| SCHEMBL14744244 | 0.80 | MAPK8 (0.49) | ALDH1A1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL14743578 | 0.79 | RORC (0.44) | KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013030358-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-03-07 | — | — | WO | disclosed |