Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1984060 | 0.98 | PABPC1 (0.42) | PABPC1APOBEC3AEIF4HAPOBEC3GKDM4E | |
| Bromide SCHEMBL14765198 | 0.96 | PABPC1 (0.41) | PABPC1APOBEC3AEIF4HAPOBEC3GKDM4E | |
| SCHEMBL16552577 | 0.92 | PABPC1 (0.38) | PABPC1APOBEC3AEIF4HAPOBEC3GKDM4E | |
| SCHEMBL16552761 | 0.88 | HPGD (0.38) | PABPC1APOBEC3AEIF4HAPOBEC3GRAB9A | |
| Trifluoromethanesulfonic Acid SCHEMBL14765272 | 0.83 | KDM1A (0.37) | PABPC1APOBEC3AEIF4HAPOBEC3GRAB9A | |
| SCHEMBL16552862 | 0.81 | TERT (0.50) | KDM4ERAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL1810828 | 0.79 | KDM4E (0.53) | KDM4ERAB9ASMN1; SMN2NPC1LOXL2 | |
| SCHEMBL14063445 | 0.78 | GAA (0.54) | KDM4ERAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL3833508 | 0.77 | KDM4E (0.52) | KDM4ERAB9ASMN1; SMN2NPC1LOXL2 | |
| Bromide SCHEMBL3837111 | 0.77 | KDM4E (0.52) | KDM4ERAB9ASMN1; SMN2NPC1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2753620-B1 | NOVEL PROCESS FOR PREPARING CEFTAROLINE FOSAMIL | SANDOZ AG (CH) | 2017-02-15 | — | — | EP | disclosed |
| US-9382278-B2 | Process for preparing ceftaroline fosamil | SANDOZ AG (CH) | 2016-07-05 | — | — | US | disclosed |
| US-20160009745-A1 | NOVEL PROCESS FOR PREPARING CEFTAROLINE FOSAMIL | SANDOZ AG (CH) | 2016-01-14 | — | — | US | disclosed |
| US-9169239-B2 | Process for preparing ceftaroline fosamil | SANDOZ AG (CH) | 2015-10-27 | — | — | US | disclosed |
| US-20150073138-A1 | NOVEL PROCESS FOR PREPARING CEFTAROLINE FOSAMIL | SANDOZ AG (CH) | 2015-03-12 | — | — | US | disclosed |
| WO-2013034718-A1 | NOVEL PROCESS FOR PREPARING CEFTAROLINE FOSAMIL | SANDOZ AG (CH) | 2013-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150073138-A1 | NOVEL PROCESS FOR PREPARING CEFTAROLINE FOSAMIL | FOS, FOSB, CYP3A7 | PABPC1 2816/4885APOBEC3A 252/4885EIF4H 1749/4885 |
| US-20160009745-A1 | NOVEL PROCESS FOR PREPARING CEFTAROLINE FOSAMIL | FOS, FOSB, CYP3A7 | PABPC1 2643/4885APOBEC3A 211/4885EIF4H 1435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.