Oxidronic Acid

Oxidronic Acid

SCHEMBL1477022

O=P([O-])([O-])C(O)P(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Oxidronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CA1 known ✓ P00915 2/20 0.32
CA4 known ✓ P22748 2/20 0.32
LMNA P02545 2/20 0.39
SLC34A1 Q06495 1/20 0.38
KDM4E B2RXH2 1/20 0.33
CYP2C19 P33261 1/20 0.33
KMT2A Q03164 1/20 0.33
CA5A P35218 2/20 0.32
CA5B Q9Y2D0 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oxidronic Acid SCHEMBL10858714 0.92 SLC34A1 (0.38) LMNASLC34A1
Oxidronic Acid SCHEMBL10862309 0.92 SLC34A1 (0.38) LMNASLC34A1
Oxidronic Acid SCHEMBL10862018 0.92 SLC34A1 (0.38) LMNASLC34A1
Oxidronic Acid SCHEMBL11106757 0.92 SLC34A1 (0.38) LMNASLC34A1CA1CA4CA5A
Oxidronic Acid SCHEMBL10862381 0.92 SLC34A1 (0.38) LMNASLC34A1
Oxidronic Acid SCHEMBL10864367 0.92 SLC34A1 (0.38) LMNASLC34A1
Oxidronic Acid SCHEMBL10860143 0.92 SLC34A1 (0.38) LMNASLC34A1
Oxidronic Acid SCHEMBL10860353 0.92 SLC34A1 (0.38) LMNASLC34A1
Oxidronic Acid SCHEMBL10858939 0.92 SLC34A1 (0.38) LMNASLC34A1
Oxidronic Acid SCHEMBL10862115 0.92 SLC34A1 (0.38) LMNASLC34A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1292338-B1 STABILISER FOR RADIOPHARMACEUTICALS GE HEALTHCARE LTD (GB) 2012-09-19 EP disclosed
US-7914768-B2 Increase shelf life with a mixture of stabilizers, comprising an amino-substituted aromatic carboxylic acid and a diphosphonic acids; radioactive metal with amine oxime complexes; nondegrading GE HEALTHCARE LIMITED (GB) 2011-03-29 US disclosed
US-20050063902-A1 Stabiliser for radiopharmaceuticals GE HEALTHCARE LIMITED (GB) 2005-03-24 US disclosed
EP-1292338-A2 STABILISER FOR RADIOPHARMACEUTICALS GE Healthcare Limited (GB) 2003-03-19 EP disclosed
WO-2001097862-A2 STABILISER FOR RADIOPHARMACEUTICALS AMERSHAM PLC (GB) 2001-12-27 WO disclosed
US-4579720-A USING HYDROXYMETHANE DIPHOSPHONIC ACID PLAINS CHEMICAL DEVELOPMENT CO. (US) 1986-04-01 US disclosed
US-4440646-A HYDROXY OR HALOALKANEPHOSPHONATES PLAINS CHEMICAL DEVELOPMENT CO. (US) 1984-04-03 US disclosed
US-4188234-A STABILIZATION OF VINYL POLYMERS, POLYPHOSPHONIC ACID CHELATING AGENT, PROTECTIVE COATINGS PLAINS CHEMICAL DEVELOPMENT CO. (US) 1980-02-12 US disclosed
US-4116990-A OF NON-ALKALI METAL IONS WITH PHOSPHORUS CHELATING COMPOUND PLAINS CHEMICAL DEVELOPMENT CO. (US) 1978-09-26 US disclosed
US-4020091-A TIN SALTS OF POLYPHOSPHONIC ACIDS PLAINS CHEMICAL DEVELOPMENT CO. (US) 1977-04-26 US disclosed