Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL170644 | 0.82 | CA1 (0.39) | KMT2AALDH1A1MAPTL3MBTL1 | |
| Zinc Ion SCHEMBL31034476 | 0.80 | CA1 (0.37) | KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL9219255 | 0.77 | CA1 (0.44) | KMT2AALDH1A1MAPTCYP1A2CYP2C9 | |
| SCHEMBL1743259 | 0.72 | TLR4 (0.32) | POLBALDH1A1MAPT | |
| Tromethamine SCHEMBL5710709 | 0.70 | LMNA (0.67) | MEN1LMNAKMT2AALDH1A1 | |
| Tromethamine SCHEMBL7347818 | 0.67 | LMNA (0.62) | MEN1LMNAKMT2APOLBALDH1A1 | |
| Tromethamine SCHEMBL19183294 | 0.67 | LMNA (0.62) | MEN1LMNAKMT2AALDH1A1 | |
| Tromethamine SCHEMBL4581519 | 0.67 | LMNA (0.62) | MEN1LMNAKMT2APOLBALDH1A1 | |
| Tromethamine SCHEMBL194002 | 0.67 | LMNA (0.62) | MEN1LMNAKMT2APOLBALDH1A1 | |
| Tromethamine SCHEMBL8525545 | 0.67 | TRIM24 (0.52) | MEN1LMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962766-B2 | Polymers functionalized with polyhydrazone compounds | BRIDGESTONE CORPORATION (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20130079463-A1 | POLYMERS FUNCTIONALIZED WITH POLYHYDRAZONE COMPOUNDS | BRIDGESTONE CORPORATION (JP) | 2013-03-28 | — | — | US | disclosed |