Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.32 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
| ▸ | ARG2 | P78540 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL194002 | 1.00 | LMNA (0.62) | LMNAMEN1KMT2AFFAR3LCK | |
| Tromethamine SCHEMBL7347818 | 1.00 | LMNA (0.62) | LMNAMEN1KMT2AFFAR3LCK | |
| Tromethamine SCHEMBL3473649 | 0.92 | LMNA (0.53) | LMNAMEN1KMT2AFFAR3LCK | |
| Tromethamine SCHEMBL5891164 | 0.92 | MEN1 (0.53) | LMNAMEN1KMT2AFFAR3LCK | |
| Tromethamine SCHEMBL5710709 | 0.90 | LMNA (0.67) | LMNAMEN1KMT2AS1PR1ALOX15 | |
| Tromethamine SCHEMBL29111702 | 0.89 | LMNA (0.50) | LMNAMEN1KMT2AFFAR3LCK | |
| Tromethamine SCHEMBL19183294 | 0.88 | LMNA (0.62) | LMNAMEN1KMT2AS1PR1ALOX15 | |
| Tromethamine SCHEMBL2898170 | 0.87 | MEN1 (0.48) | LMNAMEN1KMT2AFFAR3LCK | |
| Tromethamine SCHEMBL8668436 | 0.87 | LMNA (0.71) | LMNAMEN1KMT2AS1PR1BLM | |
| Tromethamine SCHEMBL9235516 | 0.87 | LMNA (0.71) | LMNAMEN1KMT2AS1PR1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111905584-A | Solution preparation system and integrated system | 苏州美极医疗科技有限公司 | 2020-11-10 | — | — | CN | disclosed |
| US-7371391-B2 | Papilloma virus capsomere vaccine formulations and methods of use | LOYOLA UNIVERSITY OF CHICAGO (US) | 2008-05-13 | — | — | US | disclosed |
| US-20060198853-A1 | Papilloma virus capsomere vaccine formulations and methods of use | GISSMANN LUTZ | 2006-09-07 | — | — | US | disclosed |
| US-6361778-B1 | PAPILLOMAVIRUS VIRUS-LIKE PARTICLE CONSISTING OF TRUNCATED PAPILLOMAVIRUS L1 PROTEIN CONSISTING OF AMINO ACID SEQUENCE HAVING ONE OR MORE AMINO ACID RESIDUES DELETED FROM CARBOXY TERMINUS OF FULL LENGTH L1 AMINO ACID SEQUENCE | GISSMANN LUTZ (US) | 2002-03-26 | — | — | US | disclosed |