Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.32 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL5710709 | 0.90 | LMNA (0.67) | LMNAMEN1KMT2AALOX15BLM | |
| Tromethamine SCHEMBL4581519 | 0.88 | LMNA (0.62) | LMNAMEN1KMT2AALOX15BLM | |
| Tromethamine SCHEMBL194002 | 0.88 | LMNA (0.62) | LMNAMEN1KMT2AALOX15BLM | |
| Tromethamine SCHEMBL7347818 | 0.88 | LMNA (0.62) | LMNAMEN1KMT2AALOX15BLM | |
| Tromethamine SCHEMBL6905131 | 0.87 | LMNA (0.71) | LMNAMEN1KMT2AALOX15BLM | |
| Tromethamine SCHEMBL2097922 | 0.84 | TDP1 (0.60) | LMNAMEN1KMT2AALOX15BLM | |
| Tromethamine SCHEMBL15552130 | 0.82 | LMNA (0.56) | LMNAMEN1KMT2AALOX15BLM | |
| Tromethamine SCHEMBL9115087 | 0.82 | MEN1 (0.56) | LMNAMEN1KMT2AALOX15BLM | |
| Tromethamine SCHEMBL9699085 | 0.81 | LMNA (0.62) | LMNAMEN1KMT2AALOX15BLM | |
| Tromethamine SCHEMBL22534461 | 0.80 | MEN1 (0.53) | LMNAMEN1KMT2AS1PR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266486-B2 | Method of making a composition of an alkanolamine alkylamide and a polyol | AKZO NOBEL CHEMICALS INTERNATIONAL B.V. (NL) | 2019-04-23 | — | — | US | disclosed |
| US-20190031598-A1 | METHOD OF MAKING A COMPOSITION OF AN ALKANOLAMINE ALKYLAMIDE AND A POLYOL | NOURYON CHEMICALS INTERNATIONAL B.V. (NL) | 2019-01-31 | — | — | US | disclosed |
| EP-3408255-A1 | METHOD OF MAKING A COMPOSITION OF AN ALKANOLAMINE ALKYLAMIDE AND A POLYOL | Akzo Nobel Chemicals International B.V. (NL) | 2018-12-05 | — | — | EP | disclosed |
| WO-2017129272-A1 | METHOD OF MAKING A COMPOSITION OF AN ALKANOLAMINE ALKYLAMIDE AND A POLYOL | AKZO NOBEL CHEMICALS INTERNATIONAL B.V. (NL) | 2017-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190031598-A1 | METHOD OF MAKING A COMPOSITION OF AN ALKANOLAMINE ALKYLAMIDE AND A POLYOL | PHOSPHO1, SGMS2, SGMS1 | LMNA 420/4885MEN1 1155/4885KMT2A 691/4885 |
| US-10266486-B2 | Method of making a composition of an alkanolamine alkylamide and a polyol | PHOSPHO1, SGMS2, SGMS1 | LMNA 420/4885MEN1 1155/4885KMT2A 691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.