Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.32 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
| ▸ | ARG2 | P78540 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL4581519 | 1.00 | LMNA (0.62) | LMNAMEN1KMT2AFFAR3LCK | |
| Tromethamine SCHEMBL7347818 | 1.00 | LMNA (0.62) | LMNAMEN1KMT2AFFAR3LCK | |
| Tromethamine SCHEMBL3473649 | 0.92 | LMNA (0.53) | LMNAMEN1KMT2AFFAR3LCK | |
| Tromethamine SCHEMBL5891164 | 0.92 | MEN1 (0.53) | LMNAMEN1KMT2AFFAR3LCK | |
| Tromethamine SCHEMBL5710709 | 0.90 | LMNA (0.67) | LMNAMEN1KMT2AS1PR1ALOX15 | |
| Tromethamine SCHEMBL29111702 | 0.89 | LMNA (0.50) | LMNAMEN1KMT2AFFAR3LCK | |
| Tromethamine SCHEMBL19183294 | 0.88 | LMNA (0.62) | LMNAMEN1KMT2AS1PR1ALOX15 | |
| Tromethamine SCHEMBL2898170 | 0.87 | MEN1 (0.48) | LMNAMEN1KMT2AFFAR3LCK | |
| Tromethamine SCHEMBL8668436 | 0.87 | LMNA (0.71) | LMNAMEN1KMT2AS1PR1BLM | |
| Tromethamine SCHEMBL9235516 | 0.87 | LMNA (0.71) | LMNAMEN1KMT2AS1PR1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4226 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122060923-A | Primer, probe and kit for EB virus detection | 苏州大学附属儿童医院 | 2026-05-19 | — | — | CN | claimed |
| CN-116042565-B | Taq DNA polymerase mutant for qPCR (quantitative polymerase chain reaction) by probe method | 武汉爱博泰克生物科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| EP-4719450-A2 | MODIFIED CAVEOLIN-1 PEPTIDE FORMULATIONS AND METHODS OF MANUFACTURING AND USE THEREOF | Rein Therapeutics, Inc. (US) | 2026-04-08 | — | — | EP | claimed |
| US-20260007739-A1 | HERPESVIRUS COMPOSITIONS AND RELATED METHODS | SANOFI PASTEUR LTD (CA) | 2026-01-08 | — | — | US | claimed |
| WO-2025264834-A1 | DNA (RNA) ASSEMBLY MEDIATED BY CHARGED AND CHARGE-SWITCHING PEPTIDES | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2025-12-26 | — | — | WO | claimed |
| US-20250388962-A1 | RNA MAPPING METHODS WITH HIGH SEQUENCE COVERAGE | WATERS TECHNOLOGIES CORP (US) | 2025-12-25 | — | — | US | claimed |
| US-12502383-B2 | Pharmaceutical composition of cyclooxygenase-2 inhibitors | THEMIS MEDICARE LIMITED (IN) | 2025-12-23 | — | — | US | claimed |
| US-20250368983-A1 | CONTROLLING FOR TAGMENTATION SEQUENCING LIBRARY INSERT SIZE USING ARCHAEAL HISTONE-LIKE PROTEINS | KAPA BIOSYSTEMS INC (US) | 2025-12-04 | — | — | US | claimed |
| WO-2025235739-A1 | RNA MAPPING METHODS WITH HIGH SEQUENCE COVERAGE | WATERS TECHNOLOGIES CORPORATION (US) | 2025-11-13 | — | — | WO | claimed |
| EP-4643122-A1 | A METHOD FOR FRACTIONATION OF BIOMOLECULES | Life Technologies Corporation (US) | 2025-11-05 | — | — | EP | claimed |
| US-20090269380-A1 | METHODS OF TREATING FUNGAL, YEAST AND MOLD INFECTIONS | NANOBIO CORPORATION | 2009-10-29 | — | — | US | claimed |
| EP-2089429-A2 | PROCESS FOR PREPARING UNAGGREGATED ANTIBODY FC DOMAINS | Centocor Ortho Biotech Inc. (US) | 2009-08-19 | — | — | EP | claimed |
| US-20090171072-A1 | Process for Preparing Unaggregated Antibody FC Domains | CENTOCOR ORTHO BIOTECH INC. | 2009-07-02 | — | — | US | claimed |
| WO-2008049106-A2 | PROCESS FOR PREPARING UNAGGREGATED ANTIBODY FC DOMAINS | CENTOCOR ORTHO BIOTECH INC. (US) | 2008-04-24 | — | — | WO | claimed |
| US-20080044804-A1 | COMPOSITIONS AND METHODS FOR DETECTION AND ISOLATION OF PHOSPHORYLATED MOLECULES | INVITROGEN CORPORATION (US) | 2008-02-21 | — | — | US | claimed |
| EP-1097171-B1 | METHOD FOR PURIFYING HEMOGLOBIN | BIOPURE CORP (US) | 2006-12-06 | — | — | EP | claimed |
| EP-0809700-B1 | PAPILLOMA VIRUS-LIKE PARTICLES, FUSION PROTEINS AND PROCESS FOR PRODUCING THE SAME | UNIV LOYOLA CHICAGO (US) | 2006-05-10 | — | — | EP | claimed |
| EP-1097171-A1 | METHOD FOR PURIFYING HEMOGLOBIN | BIOPURE CORPORATION (US) | 2001-05-09 | — | — | EP | claimed |
| US-6150507-A | LOADING HEMOGLOBIN SOLUTION ONTO ANION EXCHANGE CHROMATOGRAPHY COLUMN AND INJECTING TRIS(HYDROXYMETHYL) AMINOMETHANE ACETATE BUFFER SOLUTION HAVING PH LOWER THAN THAT OF COLUMN TO ELUTE PURIFIED HEMOGLOBIN; SYNTHETIC BLOOD | BIOPURE CORPORATION (US) | 2000-11-21 | — | — | US | claimed |
| WO-2000002921-A1 | METHOD FOR PURIFYING HEMOGLOBIN | BIOPURE CORPORATION (US) | 2000-01-20 | — | — | WO | claimed |