Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ERN1 | O75460 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | TLR2 | O60603 | 1/20 | 0.42 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.42 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mequinol SCHEMBL28084422 | 0.86 | TRIM24 (0.50) | ALDH1A1ERN1TUBB1CYP1A1CYP1B1 | |
| SCHEMBL1534505 | 0.85 | PRKDC (0.48) | PRKDCALDH1A1ERN1TSHRKDM4E | |
| SCHEMBL16096769 | 0.84 | PRKDC (0.42) | PRKDCALDH1A1ERN1TSHRKDM4E | |
| SCHEMBL455647 | 0.84 | LMNA (0.46) | PRKDCALDH1A1ERN1TSHRKDM4E | |
| SCHEMBL16096880 | 0.83 | TTR (0.51) | PRKDCALDH1A1ERN1TSHRKDM4E | |
| SCHEMBL3539621 | 0.83 | ALDH1A1 (0.40) | PRKDCALDH1A1ERN1TSHRPOLB | |
| SCHEMBL23706024 | 0.82 | PRKDC (0.46) | PRKDCALDH1A1ERN1TSHRKDM4E | |
| SCHEMBL6805246 | 0.82 | CYP1A1 (0.42) | ALDH1A1KDM4EPOLBMAPTKMT2A | |
| SCHEMBL16096941 | 0.82 | POLB (0.40) | PRKDCALDH1A1ERN1TSHRKDM4E | |
| SCHEMBL31474876 | 0.82 | ALDH1A1 (0.56) | ALDH1A1ERN1TSHRKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106749358-B | A method of synthesis 5- methoxyl group -4- hydroxyl -2- aldehyde radical phenyl boric acid pinacol ester | 雅本化学股份有限公司 | 2019-05-10 | — | — | CN | claimed |
| CN-106749358-A | A kind of method for synthesizing the aldehyde radical phenyl boric acid pinacol ester of 5 methoxyl group, 4 hydroxyl 2 | 雅本化学股份有限公司 | 2017-05-31 | — | — | CN | claimed |
| CN-105001107-B | A kind of method of synthesizing methyl Hongmaoxinjian | 西安交通大学 | 2016-08-17 | — | — | CN | claimed |
| US-20160083364-A1 | Phenanthridine Derivatives, Preparation Methods and Uses Thereof | CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES (CN) | 2016-03-24 | — | — | US | claimed |
| CN-105001107-A | Synthetic method for methyl caulophine | UNIV XI AN JIAOTONG | 2015-10-28 | — | — | CN | claimed |
| US-20240425452-A1 | ISOLATED TRANS ISOMER OF 3-(2-BROMO-3,4-DIHYDROXY-PHENYL)-N-(3,4,5-TRIHYDROXY-BENZYL)-THIOACRYLAMIDE | TYRNOVO LTD. (IL) | 2024-12-26 | — | — | US | disclosed |
| CN-118369091-A | Isolated trans isomer of 3- (2-bromo-3, 4-dihydroxy-phenyl) -N- (3, 4, 5-trihydroxy-benzyl) -thioacrylamide | 特尔诺沃有限公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-115466205-B | Isolated trans isomer of 3- (2-bromo-3, 4-dihydroxy-phenyl) -N- (3, 4, 5-trihydroxy-benzyl) -thioacrylamide | 特尔诺沃有限公司 | 2023-10-24 | — | — | CN | disclosed |
| EP-4201926-A1 | NOVEL INTERMEDIATE, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF | Sichuan University (CN) | 2023-06-28 | — | — | EP | disclosed |
| WO-2023079545-A1 | ISOLATED TRANS ISOMER OF 3-(2-BROMO-3,4-DIHYDROXY-PHENYL)-N-(3,4,5-TRIHYDROXY-BENZYL)-THIOACRYLAMIDE | TYRNOVO LTD. (IL) | 2023-05-11 | — | — | WO | disclosed |
| CN-111662331-B | Phosphine ligand, preparation method thereof and application of phosphine ligand in catalytic synthesis of ortho-tetra-substituted biaryl | 宁波赜军医药科技有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-115466205-A | Isolated trans isomer of 3- (2-bromo-3, 4-dihydroxy-phenyl) -N- (3, 4, 5-trihydroxy-benzyl) -thioacrylamide | 特尔诺沃有限公司 | 2022-12-13 | — | — | CN | disclosed |
| US-4342686-A | Intermediates for preparing 6-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1982-08-03 | — | — | US | disclosed |
| EP-0004794-B1 | SUBSTITUTED BENZAZEPINES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1982-04-28 | — | — | EP | disclosed |
| US-4265889-A | DOPAMINERGIC, HYPOTENSIVE | SMITHKLINE CORPORATION (US) | 1981-05-05 | — | — | US | disclosed |
| EP-0026505-A1 | 7,8-Substituted-1-phenyl-2,3,4,5-tetrahydro-1-H-3-benzazepines | SMITHKLINE BECKMAN CORPORATION (US) | 1981-04-08 | — | — | EP | disclosed |
| EP-0004794-A2 | Substituted benzazepines, processes for preparing them and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1979-10-17 | — | — | EP | disclosed |
| US-4171359-A | DOPAMINERGIC ACTIVITY | SMITHKLINE CORPORATION (US) | 1979-10-16 | — | — | US | disclosed |
| US-4165372-A | 6-Carboxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds and use as dopaminergic agents | SMITHKLINE CORPORATION (US) | 1979-08-21 | — | — | US | disclosed |
| EP-0002327-A1 | Pharmacologically active 6-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, method of preparing them and intermediates | SMITHKLINE BECKMAN CORPORATION (US) | 1979-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083364-A1 | Phenanthridine Derivatives, Preparation Methods and Uses Thereof | CTNNB1, WNT3A, WNT1 | PRKDC 3594/4885ALDH1A1 1893/4885ERN1 2510/4885 |
| US-20240425452-A1 | ISOLATED TRANS ISOMER OF 3-(2-BROMO-3,4-DIHYDROXY-PHENYL)-N-(3,4,5-TRIHYDROXY-BENZYL)-THIOACRYLAMIDE | TOP2B, TERT, TAC3 | PRKDC 4421/4885ALDH1A1 470/4885ERN1 4736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.